Tight junction structure and function revisited

T Otani, M Furuse - Trends in cell biology, 2020 - cell.com
Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …

Regulation of the intestinal barrier by nutrients: The role of tight junctions

T Suzuki - Animal Science Journal, 2020 - Wiley Online Library
Tight junctions (TJs) play an important role in intestinal barrier function. TJs in intestinal
epithelial cells are composed of different junctional molecules, such as claudin and …

[HTML][HTML] Structure, function, and regulation of the blood-brain barrier tight junction in central nervous system disorders

JJ Lochhead, J Yang, PT Ronaldson… - Frontiers in physiology, 2020 - frontiersin.org
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …

Overcoming blood–brain barrier transport: Advances in nanoparticle-based drug delivery strategies

S Ding, AI Khan, X Cai, Y Song, Z Lyu, D Du, P Dutta… - Materials today, 2020 - Elsevier
The blood–brain barrier (BBB), a unique structure in the central nervous system (CNS),
protects the brain from bloodborne pathogens by its excellent barrier properties …

The intestinal epithelial barrier: a therapeutic target?

MA Odenwald, JR Turner - Nature reviews Gastroenterology & …, 2017 - nature.com
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in …

Y Peng, Y Yan, P Wan, D Chen, Y Ding, L Ran… - Free Radical Biology …, 2019 - Elsevier
In the present study, the therapeutic effects of crude anthocyanins (ACN) from the fruits of
Lycium ruthenicum Murray and the main monomer of ACN, petunidin 3-O-[rhamnopyranosyl …

Inflammation and the intestinal barrier: leukocyte–epithelial cell interactions, cell junction remodeling, and mucosal repair

AC Luissint, CA Parkos, A Nusrat - Gastroenterology, 2016 - Elsevier
The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic,
permeable barrier allowing for selective absorption of nutrients, while restricting access to …

[HTML][HTML] Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases

SH Lee - Intestinal research, 2015 - synapse.koreamed.org
Epithelial tight junctions (TJs) are the key structures regulating paracellular trafficking of
macromolecules. The TJ is multi-protein complex that forms a selective permeable seal …

The mammalian blood-testis barrier: its biology and regulation

DD Mruk, CY Cheng - Endocrine reviews, 2015 - academic.oup.com
Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

[HTML][HTML] Enteric pathogens and their toxin-induced disruption of the intestinal barrier through alteration of tight junctions in chickens

WA Awad, C Hess, M Hess - Toxins, 2017 - mdpi.com
Maintaining a healthy gut environment is a prerequisite for sustainable animal production.
The gut plays a key role in the digestion and absorption of nutrients and constitutes an initial …