Significance of the vitamin D receptor on crosstalk with nuclear receptors and regulation of enzymes and transporters
The vitamin D receptor (VDR), in addition to other nuclear receptors, the pregnane X
receptor (PXR) and constitutive androstane receptor (CAR), is involved in the regulation of …
receptor (PXR) and constitutive androstane receptor (CAR), is involved in the regulation of …
[PDF][PDF] Biology of vitamin D
SJ Wimalawansa - J Steroids Horm Sci, 2019 - researchgate.net
Vitamin D is both a vitamin and a hormone. It has pleotropic actions that extend beyond
calcium and phosphate homeostasis, regulation of parathyroid hormone, and the prevention …
calcium and phosphate homeostasis, regulation of parathyroid hormone, and the prevention …
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice
R Jia, F Yang, P Yan, L Ma, L Yang, L Li - Free Radical Biology and …, 2021 - Elsevier
Background Clinical studies indicate that vitamin D receptor (VDR) expression is reduced in
primary biliary cirrhosis patient livers. However, the mechanism by which activated VDR …
primary biliary cirrhosis patient livers. However, the mechanism by which activated VDR …
Differential Effects of 1α,25-Dihydroxyvitamin D3 on the Expressions and Functions of Hepatic CYP and UGT Enzymes and Its Pharmacokinetic Consequences In …
The compound 1α, 25-Dihydroxyvitamin D3 (1, 25 (OH) 2D3) is the active form of vitamin D3
and a representative ligand of the vitamin D receptor (VDR). Previous studies have …
and a representative ligand of the vitamin D receptor (VDR). Previous studies have …
Vitamin D receptor-targeted treatment to prevent pathological dedifferentiation of pancreatic β cells under hyperglycaemic stress
AN John, Z Iqbal, S Colley, G Morahan… - Diabetes & …, 2018 - Elsevier
Dedifferentiation has been identified as one of the causes of β-cell failure resulting in type 2
diabetes (T2D). This study tested whether increasing vitamin D receptor (VDR) expression …
diabetes (T2D). This study tested whether increasing vitamin D receptor (VDR) expression …
Effects of 1α, 25-dihydroxyvitamin D3, the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in …
Evidence in the literature suggests that 1α, 25-dihydroxyvitamin D 3 [1, 25 (OH) 2 D 3], the
vitamin D receptor ligand, down-regulated the expression of the rat renal organic anion …
vitamin D receptor ligand, down-regulated the expression of the rat renal organic anion …
Potencies of vitamin D analogs, 1α‐hydroxyvitamin D3, 1α‐hydroxyvitamin D2 and 25‐hydroxyvitamin D3, in lowering cholesterol in hypercholesterolemic mice in vivo
HP Quach, T Dzekic, P Bukuroshi… - … & drug disposition, 2018 - Wiley Online Library
Vitamin D3 and the synthetic vitamin D analogs, 1α‐hydroxyvitamin D3 [1α (OH) D3], 1α‐
hydroxyvitamin D2 [1α (OH) D2] and 25‐hydroxyvitamin D3 [25 (OH) D3] were appraised for …
hydroxyvitamin D2 [1α (OH) D2] and 25‐hydroxyvitamin D3 [25 (OH) D3] were appraised for …
Alterations in gene expression in vitamin D‐deficiency: Down‐regulation of liver Cyp7a1 and renal Oat3 in mice
HP Quach, K Noh, SY Hoi, A Bruinsma… - … & drug disposition, 2018 - Wiley Online Library
The vitamin D‐deficient model, established in the C57BL/6 mouse after 8 weeks of feeding
vitamin D‐deficient diets in the absence or presence of added calcium, was found …
vitamin D‐deficient diets in the absence or presence of added calcium, was found …
Influence of 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 on expression of P-glycoprotein and cytochrome P450 3A in sheep
MR Wilkens, LM Maté, N Schnepel, S Klinger… - The Journal of Steroid …, 2016 - Elsevier
In order to improve calcium and phosphorus balance, beef cattle and dairy cows can be
supplemented with vitamin D. However, different vitamin D metabolites have been shown to …
supplemented with vitamin D. However, different vitamin D metabolites have been shown to …
Therapeutic targets of vitamin D receptor ligands and their pharmacokinetic effects by modulation of transporters and metabolic enzymes
Vitamin D is involved in retaining the balance of several minerals in the body, such as
calcium and phosphate, which are crucial for the bone formation and development. These …
calcium and phosphate, which are crucial for the bone formation and development. These …