Stem cell therapy in liver regeneration: Focus on mesenchymal stem cells and induced pluripotent stem cells

L Zhang, YY Fei, HT Han, J Xu, L Cheng, X Li - Pharmacology & …, 2022 - Elsevier
The liver has the ability to repair itself after injury; however, a variety of pathological changes
in the liver can affect its ability to regenerate, and this could lead to liver failure …

Reprogramming of tissue metabolism during cancer metastasis

K Ganguly, AC Kimmelman - Trends in cancer, 2023 - cell.com
Cancer is a systemic disease that involves malignant cell-intrinsic and-extrinsic metabolic
adaptations. Most studies have tended to focus on elucidating the metabolic vulnerabilities …

HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications

E Cuttini, C Goi, E Pellarin, R Vida… - Frontiers in molecular …, 2023 - frontiersin.org
Controlling access to genomic information and maintaining its stability are key aspects of
cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA …

Dynamics of hepatocyte-cholangiocyte cell-fate decisions during liver development and regeneration

S Sahoo, A Mishra, AM Diehl, MK Jolly - Iscience, 2022 - cell.com
The immense regenerative potential of the liver is attributed to the ability of its two key cell
types–hepatocytes and cholangiocytes–to trans-differentiate to one another either directly or …

DNA methylation in cell plasticity and malignant transformation in liver diseases

M Kim, E Delgado, S Ko - Pharmacology & therapeutics, 2023 - Elsevier
The liver possesses extraordinary regenerative capacity mainly attributable to the ability of
hepatocytes (HCs) and biliary epithelial cells (BECs) to self-replicate. This ability is left over …

Newer mitochondrial dynamics and their role of calcium signalling in liver regeneration

O Bedi, V Sapra, M Kumar, P Krishan - Mitochondrion, 2024 - Elsevier
Liver regeneration is a crucial process involved in cellular proliferation, differentiation, and
tissue repair. Calcium signaling impact key pathways like hepatocyte growth factor-Met …

The influence of tissue spatial geometry and functional organisation on liver regeneration

L Aloia - Seminars in cell & developmental biology, 2022 - Elsevier
The adult liver exerts crucial functions, including nutrient metabolism and storage, bile
production and drug detoxification. These complex functions expose the liver to constant …

[HTML][HTML] miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes

D Salerno, G Peruzzi, GR Pascucci, M Levrero… - Gene, 2024 - Elsevier
Background Epigenetic mechanisms, including DNA methylation, histone modifications, and
chromatin remodeling, are highly involved in the regulation of hepatocyte viability …

Epigenetic-based antioxidant effect of an ethanolic extract of Corylus avellana L. on THLE-2 human primary hepatocytes

B Benassi, L Bacchetta, O Maccioni… - Natural Product …, 2023 - Taylor & Francis
The ethanolic extract of Corylus avellana L hazelnut, prepared in our laboratories, has been
previously characterized by liquid chromatography coupled to high resolution mass …

Quantifying tissue response after intraovarian platelet-rich plasma: Experimental approach to assess NF-κB and TNF-α as mediators to reduce local entropy

ES Sills - 2023 - preprints.org
Diminished ovarian reserve can be regarded as a sentinel indicator to foreshadow severe
follicular loss and, ultimately, systemic aging. The negative slope of human ovulatory fidelity …