The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases
High heterogeneity of macrophage is associated with its functions in polarization to different
functional phenotypes depending on environmental cues. Macrophages remain in balanced …
functional phenotypes depending on environmental cues. Macrophages remain in balanced …
Effect of reactive oxygen species on the endoplasmic reticulum and mitochondria during intracellular pathogen infection of mammalian cells
J Lee, CH Song - Antioxidants, 2021 - mdpi.com
Oxidative stress, particularly reactive oxygen species (ROS), are important for innate
immunity against pathogens. ROS directly attack pathogens, regulate and amplify immune …
immunity against pathogens. ROS directly attack pathogens, regulate and amplify immune …
Role of apoptosis and autophagy in tuberculosis
A Lam, R Prabhu, CM Gross… - … of Physiology-Lung …, 2017 - journals.physiology.org
Tuberculosis (TB) is one of the oldest known human diseases and is transmitted by the
bacteria Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB …
bacteria Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB …
Critical role of calpain in inflammation
J Ji, L Su, Z Liu - Biomedical reports, 2016 - spandidos-publications.com
Calpains are a family of cysteine proteases, implicated in a wide range of cellular calcium‑
regulated functions. Evidence from previous studies using an inhibitor of calpain indicates …
regulated functions. Evidence from previous studies using an inhibitor of calpain indicates …
Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections
Alteration of macrophage function has an important regulatory impact on the survival of
intracellular mycobacteria. We found that macrophages infected with attenuated …
intracellular mycobacteria. We found that macrophages infected with attenuated …
[HTML][HTML] Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation
Both calpain activation and endoplasmic reticulum (ER) stress are implicated in ischemic
heart injury. However, the role of calpain in ER stress remains largely elusive. This study …
heart injury. However, the role of calpain in ER stress remains largely elusive. This study …
Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line
Y Cui, D Zhao, S Sreevatsan, C Liu, W Yang… - Frontiers in cellular …, 2016 - frontiersin.org
Mycobacterium bovis (M. bovis) is highly adapted to macrophages and has developed
multiple mechanisms to resist intracellular assaults. However, the host cells in turn deploy a …
multiple mechanisms to resist intracellular assaults. However, the host cells in turn deploy a …
Regulation of Three Virulence Strategies of Mycobacterium tuberculosis: A Success Story
Tuberculosis remains one of the deadliest diseases. Emergence of drug-resistant and
multidrug-resistant M. tuberculosis strains makes treating tuberculosis increasingly …
multidrug-resistant M. tuberculosis strains makes treating tuberculosis increasingly …
Mycobacterium tuberculosis 38-kDa antigen induces endoplasmic reticulum stress-mediated apoptosis via toll-like receptor 2/4
Endoplasmic reticulum (ER) stress responses play critical roles in the pathogenesis of
tuberculosis. To investigate the regulatory role of the ER stress response in 38-kDa antigen …
tuberculosis. To investigate the regulatory role of the ER stress response in 38-kDa antigen …
Mycobacterium fortuitum-induced ER-Mitochondrial calcium dynamics promotes calpain/caspase-12/caspase-9 mediated apoptosis in fish macrophages
Mycobacterium fortuitum is a natural fish pathogen. It induces apoptosis in headkidney
macrophages (HKM) of catfish, Clarias sp though the mechanism remains largely unknown …
macrophages (HKM) of catfish, Clarias sp though the mechanism remains largely unknown …