The impact of the microbiota-gut-brain axis on Alzheimer's disease pathophysiology
The gut microbiota is a complex ecosystem that comprises of more than 100 trillion symbiotic
microbial cells. The microbiota, the gut, and the brain form an association,'the microbiota-gut …
microbial cells. The microbiota, the gut, and the brain form an association,'the microbiota-gut …
TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer's disease
Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the
brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau …
brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau …
Periodontal microorganisms and Alzheimer disease–A causative relationship?
G Jungbauer, A Stähli, X Zhu… - Periodontology …, 2022 - Wiley Online Library
In the initiation or exacerbation of Alzheimer disease, the dissemination of oral
microorganisms into the brain tissue or the low‐level systemic inflammation have been …
microorganisms into the brain tissue or the low‐level systemic inflammation have been …
[HTML][HTML] Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice
Background The results from cross sectional and longitudinal studies show that periodontitis
is closely associated with cognitive impairment (CI) and Alzhemer's Disease (AD). Further …
is closely associated with cognitive impairment (CI) and Alzhemer's Disease (AD). Further …
Lipopolysaccharide associates with amyloid plaques, neurons and oligodendrocytes in Alzheimer's disease brain: a review
This review proposes that lipopolysaccharide (LPS, found in the wall of all Gram-negative
bacteria) could play a role in causing sporadic Alzheimer's disease (AD). This is based in …
bacteria) could play a role in causing sporadic Alzheimer's disease (AD). This is based in …
Porphyromonas gingivalis and Its Systemic Impact: Current Status
The relationship between periodontitis and systemic diseases, notably including
atherosclerosis and diabetes, has been studied for several years. Porphyromonas …
atherosclerosis and diabetes, has been studied for several years. Porphyromonas …
The role of periodontitis and periodontal bacteria in the onset and progression of Alzheimer's disease: a systematic review
M Dioguardi, V Crincoli, L Laino, M Alovisi… - Journal of clinical …, 2020 - mdpi.com
The evidence of a connection between the peripheral inflammatory processes and
neurodegenerative diseases of the central nervous system is becoming more apparent. This …
neurodegenerative diseases of the central nervous system is becoming more apparent. This …
Cathepsin B gene knockout improves behavioral deficits and reduces pathology in models of neurologic disorders
G Hook, T Reinheckel, J Ni, Z Wu, M Kindy… - Pharmacological …, 2022 - ASPET
Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …
Can an infection hypothesis explain the beta amyloid hypothesis of Alzheimer's disease?
Alzheimer's disease (AD) is the most frequent type of dementia. The pathological hallmarks
of the disease are extracellular senile plaques composed of beta-amyloid peptide (Aβ) and …
of the disease are extracellular senile plaques composed of beta-amyloid peptide (Aβ) and …
Time to test antibacterial therapy in Alzheimer's disease
Alzheimer's disease is associated with cerebral accumulation of amyloid-β peptide and
hyperphosphorylated tau. In the past 28 years, huge efforts have been made in attempting to …
hyperphosphorylated tau. In the past 28 years, huge efforts have been made in attempting to …