This review is the tenth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

Neurological disease and disorders remain a large public health threat. Thus, research to
improve early detection and/or develop more effective treatment approaches are necessary …

大脑是人体内结构最精细, 功能最复杂的高级器官, 其化学物质种类众多, 功能多样,
作用机制复杂. 研究证明, 脑中枢神经系统疾病的病变脑组织都涉及到一些神经分子的改变 …

This outlook explores how two different molecular imaging approaches might be combined
to gain insight into dynamic, subcellular metabolic processes. Specifically, we discuss how …

Technologies assessing the lipidomics, genomics, epigenomics, transcriptomics, and
proteomics of tissue samples at single-cell resolution have deepened our understanding of …

Background Syringomyelia (SM) is characterized by the development of fluid-filled cavities,
referred to as syrinxes, within the spinal cord tissue. The molecular etiology of SM post …

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas arising from
peripheral nerves, accounting for 3% to 5% of soft tissue sarcomas. MPNSTs often recur …

Inflammation is a complex process that accompanies many pathologies. Actually,
dysregulation of the inflammatory process is behind many autoimmune diseases. Thus …

Objectives Diabetes-induced peripheral nerve fiber damage can cause painful diabetic
polyneuropathy (PDPN), induced by central sensitization through proinflammatory …

On-tissue chemical derivatization is a valuable tool for expanding compound coverage in
untargeted metabolomic studies with matrix-assisted laser desorption/ionization mass …