The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all
cellular and physiological functions. It is paramount for cells to reprogram gene expression …

The AP-1 transcription factor is mainly composed of Jun, Fos and ATF protein dimers. It
mediates gene regulation in response to a plethora of physiological and pathological stimuli …

By its action on rhodopsin, light triggers the well-known visual transduction cascade, but can
also induce cell damage and death through phototoxic mechanisms–a comprehensive …

Human retinal dystrophies and degenerations and light-induced retinal degenerations in
animal models are sharing an important feature: visual cell death by apoptosis. Studying …

Binding sites for the dimeric transcription factor activator protein (AP)-1 are found in
numerous immunoregulatory and inflammatory genes. The precise mechanisms by which …

Prostate cancer is a major global health concern with limited treatment options for advanced
disease. Its heterogeneity challenges the identification of crucial driver genes implicated in …

The cornerstone of humoral immunity is the differentiation of B cells into antibody-secreting
plasma cells. This process is tightly controlled by a regulatory gene network centered on the …

In the following a surprising effect of light upon the retina of albino and pigmented rats will
be described. It was discovered when “normal” unanesthetized and unrestrained rats were …

Prostate cancer is the second most diagnosed cancer in men. It is a slow progressing
cancer, but when the disease reaches an advanced stage, treatment options are limited …

purpose. To test whether introduction of the Rpe65Leu 450 variant can overcome protection
against light-induced photoreceptor apoptosis in mice without the activator protein (AP)-1 …