Obesity is associated with a range of health outcomes that are of clinical and public health
significance, including cancer. Herein, we summarize epidemiologic and preclinical …

Animal studies and human observational data link energy restriction (ER) to reduced rates of
carcinogenesis. Most of these studies have involved continuous energy restriction (CER) …

Background: The problems of adherence to energy restriction in humans are well known.
Objective: To compare the feasibility and effectiveness of intermittent continuous energy …

Failure to recognize that many standard control rats and mice used in biomedical research
are sedentary, obese, glucose intolerant, and on a trajectory to premature death may …

Colorectal cancer has the second highest cancer-related mortality rate, with an estimated
881,000 deaths worldwide in 2018. The urgent need to reduce the incidence and mortality …

Purpose: Metastatic breast cancer is devastating and triple negative breast cancers (TNBC)
have a higher propensity for metastasis. Improved local control upfront in this aggressive …

As the link between obesity and metabolic syndrome and cancer becomes clearer, the need
to determine the optimal way to incorporate dietary manipulation in the treatment of cancer …

Undernutrition without malnutrition is an intervention that enhances laboratory animal life
span, and is widely studied to uncover factors limiting longevity. In a search of the literature …

Polycystic ovary syndrome (PCOS) is a common endocrine system disorder among women
of reproductive age. In several cases, PCOS women show infertility or subfertility and other …

INTRODUCTION Caloric restriction (CR) delays cancer growth in animals, though
translation to humans is difficult. We hypothesized intermittent fasting (ie, intermittent …