Zinc in the brain: friend or foe?
Zinc is a trace metal ion in the central nervous system that plays important biological roles,
such as in catalysis, structure, and regulation. It contributes to antioxidant function and the …
such as in catalysis, structure, and regulation. It contributes to antioxidant function and the …
The pathophysiological role of CoA
A Czumaj, S Szrok-Jurga, A Hebanowska… - International Journal of …, 2020 - mdpi.com
The importance of coenzyme A (CoA) as a carrier of acyl residues in cell metabolism is well
understood. Coenzyme A participates in more than 100 different catabolic and anabolic …
understood. Coenzyme A participates in more than 100 different catabolic and anabolic …
Impact of zinc transport mechanisms on embryonic and brain development
J Willekens, LW Runnels - Nutrients, 2022 - mdpi.com
The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn
flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence …
flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence …
Recent advances in metalloproteomics
JPC Coverdale, S Polepalli, MAZ Arruda, ABS Da Silva… - Biomolecules, 2024 - mdpi.com
Interactions between proteins and metal ions and their complexes are important in many
areas of the life sciences, including physiology, medicine, and toxicology. Despite the …
areas of the life sciences, including physiology, medicine, and toxicology. Despite the …
Characterization of the spatial distribution of metals and profile of metalloprotein complexes in a mouse model of repetitive mild traumatic brain injury
Metal dyshomeostasis is a well-established consequence of neurodegenerative diseases
and traumatic brain injury. While the significance of metals continues to be uncovered in …
and traumatic brain injury. While the significance of metals continues to be uncovered in …
Distribution of Copper, Iron, and Zinc in the Retina, Hippocampus, and Cortex of the Transgenic APP/PS1 Mouse Model of Alzheimer's Disease
SM Hosseinpour Mashkani, DP Bishop, N Raoufi-Rad… - Cells, 2023 - mdpi.com
A mis-metabolism of transition metals (ie, copper, iron, and zinc) in the brain has been
recognised as a precursor event for aggregation of Amyloid-β plaques, a pathological …
recognised as a precursor event for aggregation of Amyloid-β plaques, a pathological …
Deciphering the role of metal and non-metals in the treatment of epilepsy
Metals and non-metals have known to play a significant role in various physiological roles in
the body including the central nervous system (CNS). The alterations in their concentration …
the body including the central nervous system (CNS). The alterations in their concentration …
An Endoplasmic Reticulum-Targeted Ratiometric Fluorescent Molecule Reveals Zn2+ Micro-Dynamics During Drug-Induced Organelle Ionic Disorder
The endoplasmic reticulum (ER) is the main storage site of Zn2+, and Zn2+ plays an
important role in regulating ER homeostasis. Therefore, we designed and synthesized a …
important role in regulating ER homeostasis. Therefore, we designed and synthesized a …
Unravelling neurological disorders through metallomics-based approaches
JR de Jesus, MAZ Arruda - Metallomics, 2020 - academic.oup.com
Understanding the biological process involving metals and biomolecules in the brain is
essential for establishing the origin of neurological disorders, such as neurodegenerative …
essential for establishing the origin of neurological disorders, such as neurodegenerative …
[HTML][HTML] GRN knockdown regulates the expression and alternative splicing of genes associated with aphasia-related diseases in PC12 cells
Y Xi, M Abuduxiku, M Qu - Brain Research, 2024 - Elsevier
Background Prior research has shown that granulin precursor (GRN, also termed PGRN) is
closely linked to aphasia. However, there has been little research on the mechanism of …
closely linked to aphasia. However, there has been little research on the mechanism of …