Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Background The heterogeneity of mesenchymal stem cells (MSCs) is poorly understood,
thus limiting clinical application and basic research reproducibility. Advanced single‐cell …

Abstract 3D printing technique is the most sophisticated technique to produce scaffolds with
tailorable physical properties. But, these scaffolds often suffer from limited biological …

Titanium implants have been widely applied in dentistry and orthopedics due to their
biocompatibility and resistance to mechanical fatigue. TiO2 nanotube arrays (TiO2 NTAs) on …

Osteoblast cell adhesion is the initial step of early osseointegration responding to bone
material implants. Enhancing the osteoblastic cell adhesion has become one of the prime …

Patients with diseased/damaged bones are increasingly in need of bone replacement,
tissue regeneration, and organ repairs. The shape and size of the injury vary from person to …

A leading strategy in tissue engineering is the design of biomimetic scaffolds that stimulate
the body's repair mechanisms through the recruitment of endogenous stem cells to sites of …

Tissue engineering (TE)-based bone grafts are favorable alternatives to autografts and
allografts. Both biochemical properties and the architectural features of TE scaffolds are …

In the field of regenerative medicine, human mesenchymal stem cells envisage extremely
promising applications, due to their ability to differentiate into a wide range of connective …