Porcine circovirus type 2 (PCV2) vaccines in the context of current molecular epidemiology

AK Karuppannan, T Opriessnig - Viruses, 2017 - mdpi.com
Porcine circovirus type 2 (PCV2) is an economically important swine pathogen and,
although small, it has the highest evolution rate among DNA viruses. Since the discovery of …

Current understanding of genomic DNA of porcine circovirus type 2

Q Lv, K Guo, Y Zhang - Virus genes, 2014 - Springer
Abstract Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-
associated diseases in swine and is also described as the modulator of host immunity that …

Identification and functional analysis of the novel ORF4 protein encoded by porcine circovirus type 2

J He, J Cao, N Zhou, Y Jin, J Wu, J Zhou - Journal of virology, 2013 - Am Soc Microbiol
ABSTRACT Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine
circovirus-associated diseases in pigs. To date, viral proteins Cap, Rep, Rep′, and ORF3 …

Antibody recognition of porcine circovirus type 2 capsid protein epitopes after vaccination, infection, and disease

BR Trible, M Kerrigan, N Crossland… - Clinical and vaccine …, 2011 - Am Soc Microbiol
ABSTRACT Open reading frame 2 (ORF2) of porcine circovirus type 2 (PCV2) codes for the
233-amino-acid capsid protein (CP). Baculovirus-based vaccines that express only ORF2 …

Interactions of porcine circovirus 2 with its hosts

L Ren, X Chen, H Ouyang - Virus genes, 2016 - Springer
Abstract Porcine circovirus 2 (PCV2) can cause porcine circovirus diseases and porcine
circovirus-associated diseases (PCVD/PCVAD), which are widely presented in swine …

Identification of putative ORF5 protein of porcine circovirus type 2 and functional analysis of GFP-fused ORF5 protein

Q Lv, K Guo, H Xu, T Wang, Y Zhang - PLoS One, 2015 - journals.plos.org
Porcine circovirus type 2 (PCV2) is the essential infectious agent responsible for causing
porcine circovirus-associated diseases in pigs. To date, eleven RNAs and five viral proteins …

Porcine circovirus type 2 (PCV2) Cap and Rep proteins are involved in the development of cell-mediated immunity upon PCV2 infection

M Fort, M Sibila, M Nofrarías, E Pérez-Martín… - Veterinary immunology …, 2010 - Elsevier
The aim of the present study was to investigate the role of the capside (Cap) and replicase
(Rep) proteins of Porcine circovirus type 2 (PCV2) as well as the whole PCV2 (both PCV2a …

[HTML][HTML] Porcine circovirus type 2 activates PI3K/Akt and p38 MAPK pathways to promote interleukin-10 production in macrophages via Cap interaction of gC1qR

Q Du, Y Huang, T Wang, X Zhang, Y Chen, B Cui, D Li… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Porcine circovirus type 2 (PCV2) infection caused PCV2-associated diseases
(PCVAD) is one of the major emerging immunosuppression diseases in pig industry. In this …

Circoviruses

J Segalés, GM Allan, M Domingo - Diseases of swine, 2019 - Wiley Online Library
Porcine circoviruses (PCVs) belong to the genus Circovirus in the family Circoviridae. Three
PCV types have been described: PCV1, PCV2, and PCV3. PCV1 is nonpathogenic to swine …

ORF4-protein deficient PCV2 mutants enhance virus-induced apoptosis and show differential expression of mRNAs in vitro

Z Gao, Q Dong, Y Jiang, T Opriessnig, J Wang, Y Quan… - Virus research, 2014 - Elsevier
Abstract Porcine circovirus type 2 (PCV2) is the essential infectious agent of PCV associated
disease (PCVAD). During previous in vitro studies, 11 RNAs and four viral proteins have …