Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and
pose major challenges for societies with rapidly aging populations. Human genetics studies …

Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …

Neurodegenerative diseases are a large group of disabling disorders of the nervous system,
characterized by the relative selective death of neuronal subtypes. In most cases, there is …

PGC1α is a transcriptional coactivator that is a central inducer of mitochondrial biogenesis in
cells. Recent work highlighted that PGC1α can also modulate the composition and functions …

Neurodegenerative diseases selectively target subpopulations of neurons, leading to the
progressive failure of defined brain systems, but the basis of such selective neuronal …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …