[HTML][HTML] Feedback regulation of RTK signaling in development

CL Neben, M Lo, N Jura, OD Klein - Developmental biology, 2019 - Elsevier
Precise regulation of the amplitude and duration of receptor tyrosine kinase (RTK) signaling
is critical for the execution of cellular programs and behaviors. Understanding these control …

Racial and ethnic disparities in early treatment with immunotherapy for advanced HCC in the United States

JC Ahn, M Lauzon, M Luu, M Noureddin, W Ayoub… - Hepatology, 2022 - journals.lww.com
Conclusions Immunotherapy was associated with improved OS compared with
chemotherapy in advanced HCC. There are significant disparities in early access to …

Berberine attenuates cerebral ischemia-reperfusion injury induced neuronal apoptosis by down-regulating the CNPY2 signaling pathway

L Zhao, H Li, Q Gao, J Xu, Y Zhu, M Zhai… - Frontiers in …, 2021 - frontiersin.org
Berberine (BBR) has a neuroprotective effect against ischemic stroke, but its specific
protective mechanism has not been clearly elaborated. This study explored the effect of BBR …

Progress in Research on CNPY2 in Diseases

K Chen, Y Zhang, Z Wang… - Mini Reviews in Medicinal …, 2024 - ingentaconnect.com
Canopy FGF signaling regulator 2 (CNPY2) is a novel angiogenic growth factor. In recent
years, increasing evidence highlights that CNPY2 has important functions in health and …

CNPY2 is a key initiator of the PERK–CHOP pathway of the unfolded protein response

F Hong, B Liu, BX Wu, J Morreall, B Roth… - Nature structural & …, 2017 - nature.com
The unfolded protein response (UPR) in the endoplasmic reticulum (ER) is a highly
conserved protein-quality-control mechanism critical for cells to make survival-or-death …

Silencing of CDC42 inhibits contraction and growth-related functions in prostate stromal cells, which is mimicked by ML141

R Wang, R Huang, Y Liu, A Tamalunas, CG Stief… - Life Sciences, 2023 - Elsevier
Background Prostate smooth muscle contraction and stromal growth may contribute to lower
urinary tract symptoms suggestive of benign prostatic hyperplasia, but are incompletely …

Canopy 2 attenuates the transition from compensatory hypertrophy to dilated heart failure in hypertrophic cardiomyopathy

J Guo, A Mihic, J Wu, Y Zhang, K Singh… - European heart …, 2015 - academic.oup.com
Aims A mismatch between adequate angiogenesis and overgrowth of myocytes may be a
critical mechanism controlling the transition from adaptive hypertrophy to heart failure …

miR‑30a‑3p suppresses the proliferation and migration of lung adenocarcinoma cells by downregulating CNPY2

H Wang, D Kanmangne, R Li, Z Qian… - Oncology …, 2020 - spandidos-publications.com
Lung cancer is a leading cause of cancer‑related morbidity and mortality worldwide.
Although there are currently various therapeutic strategies including surgery, chemotherapy …

Targeting NPM1 epigenetically promotes postinfarction cardiac repair by reprogramming reparative macrophage metabolism

S Zhang, Y Zhang, X Duan, B Wang, Z Zhan - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Reparative macrophages play a crucial role in limiting excessive fibrosis
and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of …

Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway

J Li, L Huang, W Xiong, Y Qian, M Song - Biochemical and Biophysical …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent, and physical exercise
represents one of the most effective methods to attenuate NAFLD. However, the mechanism …