[HTML][HTML] Feedback regulation of RTK signaling in development
Precise regulation of the amplitude and duration of receptor tyrosine kinase (RTK) signaling
is critical for the execution of cellular programs and behaviors. Understanding these control …
is critical for the execution of cellular programs and behaviors. Understanding these control …
Racial and ethnic disparities in early treatment with immunotherapy for advanced HCC in the United States
JC Ahn, M Lauzon, M Luu, M Noureddin, W Ayoub… - Hepatology, 2022 - journals.lww.com
Conclusions Immunotherapy was associated with improved OS compared with
chemotherapy in advanced HCC. There are significant disparities in early access to …
chemotherapy in advanced HCC. There are significant disparities in early access to …
Berberine attenuates cerebral ischemia-reperfusion injury induced neuronal apoptosis by down-regulating the CNPY2 signaling pathway
L Zhao, H Li, Q Gao, J Xu, Y Zhu, M Zhai… - Frontiers in …, 2021 - frontiersin.org
Berberine (BBR) has a neuroprotective effect against ischemic stroke, but its specific
protective mechanism has not been clearly elaborated. This study explored the effect of BBR …
protective mechanism has not been clearly elaborated. This study explored the effect of BBR …
Progress in Research on CNPY2 in Diseases
K Chen, Y Zhang, Z Wang… - Mini Reviews in Medicinal …, 2024 - ingentaconnect.com
Canopy FGF signaling regulator 2 (CNPY2) is a novel angiogenic growth factor. In recent
years, increasing evidence highlights that CNPY2 has important functions in health and …
years, increasing evidence highlights that CNPY2 has important functions in health and …
CNPY2 is a key initiator of the PERK–CHOP pathway of the unfolded protein response
F Hong, B Liu, BX Wu, J Morreall, B Roth… - Nature structural & …, 2017 - nature.com
The unfolded protein response (UPR) in the endoplasmic reticulum (ER) is a highly
conserved protein-quality-control mechanism critical for cells to make survival-or-death …
conserved protein-quality-control mechanism critical for cells to make survival-or-death …
Silencing of CDC42 inhibits contraction and growth-related functions in prostate stromal cells, which is mimicked by ML141
R Wang, R Huang, Y Liu, A Tamalunas, CG Stief… - Life Sciences, 2023 - Elsevier
Background Prostate smooth muscle contraction and stromal growth may contribute to lower
urinary tract symptoms suggestive of benign prostatic hyperplasia, but are incompletely …
urinary tract symptoms suggestive of benign prostatic hyperplasia, but are incompletely …
Canopy 2 attenuates the transition from compensatory hypertrophy to dilated heart failure in hypertrophic cardiomyopathy
J Guo, A Mihic, J Wu, Y Zhang, K Singh… - European heart …, 2015 - academic.oup.com
Aims A mismatch between adequate angiogenesis and overgrowth of myocytes may be a
critical mechanism controlling the transition from adaptive hypertrophy to heart failure …
critical mechanism controlling the transition from adaptive hypertrophy to heart failure …
miR‑30a‑3p suppresses the proliferation and migration of lung adenocarcinoma cells by downregulating CNPY2
H Wang, D Kanmangne, R Li, Z Qian… - Oncology …, 2020 - spandidos-publications.com
Lung cancer is a leading cause of cancer‑related morbidity and mortality worldwide.
Although there are currently various therapeutic strategies including surgery, chemotherapy …
Although there are currently various therapeutic strategies including surgery, chemotherapy …
Targeting NPM1 epigenetically promotes postinfarction cardiac repair by reprogramming reparative macrophage metabolism
S Zhang, Y Zhang, X Duan, B Wang, Z Zhan - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Reparative macrophages play a crucial role in limiting excessive fibrosis
and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of …
and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of …
Aerobic exercise improves non-alcoholic fatty liver disease by down-regulating the protein expression of the CNPY2-PERK pathway
J Li, L Huang, W Xiong, Y Qian, M Song - Biochemical and Biophysical …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent, and physical exercise
represents one of the most effective methods to attenuate NAFLD. However, the mechanism …
represents one of the most effective methods to attenuate NAFLD. However, the mechanism …