Abstract Major advances in Antiretroviral Therapy (ART) have resulted in a dramatic decline
in HIV-related deaths. However, no current treatment regimen leads to viral eradication or …

CD4+ T cells orchestrate adaptive immune responses through their capacity to recruit and
provide help to multiple immune effectors, in addition to exerting direct effector functions …

Cellular immunity is critical for controlling intracellular pathogens, but individual cellular
dynamics and cell–cell cooperativity in evolving human immune responses remain poorly …

The functional avidity is determined by exposing T‐cell populations in vitro to different
amounts of cognate antigen. T‐cells with high functional avidity respond to low antigen …

ABSTRACT T-cell receptors recognize peptides presented by the major histocompatibility
complex (MHC) on the surface of antigen-presenting cells (APC). The ability of the T-cell …

Cytotoxic CD8 T lymphocytes that are present in tumors and capable of recognizing tumor
epitopes are nevertheless generally important in eliciting tumor rejection. NY-ESO-1 is a …

SARS-CoV-2 infection takes a mild or clinically inapparent course in the majority of humans
who contract this virus. After such individuals have cleared the virus, only the detection of …

Current HIV vaccines designed to stimulate CD8+ T cells have failed to induce immunologic
control upon infection. The functions of vaccine-induced HIV-specific CD8+ T cells were …

HIV infection profoundly affects many parameters of the immune system and ultimately leads
to AIDS, yet which factors are most important for determining resistance, pathology, and …

Select CMV epitopes drive life-long CD8+ T cell memory inflation, but the extent of CD4
memory inflation is poorly studied. CD4+ T cells specific for human CMV (HCMV) are …