Antibiotic-induced collateral damage to the microbiota and associated infections

L de Nies, CM Kobras, M Stracy - Nature Reviews Microbiology, 2023 - nature.com
Antibiotics have transformed medicine, saving millions of lives since they were first used to
treat a bacterial infection. However, antibiotics administered to target a specific pathogen …

[HTML][HTML] Reservoirs of antimicrobial resistance in the context of One Health

M Despotovic, L de Nies, SB Busi, P Wilmes - Current opinion in …, 2023 - Elsevier
Highlights•AMR is a leading and constantly growing threat to global health.•The human
microbiome is an important AMR reservoir.•Human–animal–environment interactions favor …

Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients

J Diaz Caballero, RM Wheatley, N Kapel… - Nature …, 2023 - nature.com
Antibiotic resistance poses a global health threat, but the within-host drivers of resistance
remain poorly understood. Pathogen populations are often assumed to be clonal within …

Recent advances in strategies to combat bacterial drug resistance: antimicrobial materials and drug delivery systems

J Yao, P Zou, Y Cui, L Quan, C Gao, Z Li, W Gong… - Pharmaceutics, 2023 - mdpi.com
Bacterial infection is a common clinical disease. Antibiotics have saved countless lives since
their discovery and are a powerful weapon in the fight against bacteria. However, with the …

Within-host evolution of bacterial pathogens in acute and chronic infection

JP Dekker - Annual Review of Pathology: Mechanisms of …, 2024 - annualreviews.org
Bacterial pathogens undergo remarkable adaptive change in response to the selective
forces they encounter during host colonization and infection. Studies performed over the …

[HTML][HTML] Lung microbiome and origins of the respiratory diseases

J Belizário, M Garay-Malpartida, J Faintuch - Current Research in …, 2023 - Elsevier
The studies on the composition of the human microbiomes in healthy individuals, its
variability in the course of inflammation, infection, antibiotic therapy, diets and different …

Genomic characterization of Pseudomonas spp. on food: implications for spoilage, antimicrobial resistance and human infection

SJ Bloomfield, R Palau, ER Holden, MA Webber… - BMC microbiology, 2024 - Springer
Background Pseudomonas species are common on food, but their contribution to the
antimicrobial resistance gene (ARG) burden within food or as a source of clinical infection is …

Analysis of metagenome and metabolome disclosed the mechanisms of Dendrobium officinale polysaccharide on DSS-induced ulcerative colitis-affected mice

X Zeng, S Tang, X Dong, M Dong, R Shao, R Liu… - International Journal of …, 2024 - Elsevier
Currently, there is no known cause for ulcerative colitis (UC), an inflammatory bowel disease
that is difficult to treat. This assay aimed to investigate the protective effects and mechanisms …

Gut microbiota regulate migration of lymphocytes from gut to lung

S Ni, X Yuan, Q Cao, Y Chen, X Peng, J Lin, Y Li… - Microbial …, 2023 - Elsevier
The community of microorganisms known as gut microbiota that lives in the intestine confers
significant health benefits on its host, primarily in the form of immunological homeostasis …

The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment

N Alvarado-Peña, D Galeana-Cadena… - Frontiers in …, 2023 - frontiersin.org
Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB)
that remains a significant global health challenge. The extensive use of antibiotics in …