Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …

Chronic stress and the accompanying long-term elevation of glucocorticoids (GCs), the
stress hormones of the body, increase the risk and accelerate the progression of Alzheimer's …

Abstract Proximity Extension Assay (PEA) and mass spectrometry (MS) methodologies were
utilized for the proteomic and lipidomic characterization of plasma specimens from patients …

In the brain, the extracellular matrix (ECM) composition shapes the neuronal
microenvironment and can undergo substantial changes with cerebral pathology. Brevican …

Background: Concomitant cerebrovascular diseases (CeVD) have been identified as an
important determinant of Alzheimer's disease (AD) progression. Development of robust …

Background Immune dysregulation has been identified as a contributing factor in the
pathophysiology of schizophrenia. This study aimed to investigate variations in specific …

In Alzheimer's Disease (AD), amyloidogenic proteins (APs), such as β-amyloid (Aβ) and tau,
may act as alarmins/damage-associated molecular patterns (DAMPs) to stimulate …

Introduction Microglia, the primary immune cells in the brain, play multifaceted roles in
Alzheimer's disease (AD). Microglia can potentially mitigate the pathological progression of …

Platelet activation of protease-activated receptor 4 (PAR4) and thrombin are at the top of a
chain of events leading to fibrin deposition, microinfarcts, blood-brain barrier disruption, and …

Purpose To screen the neurocognitive impairment persistent post-COVID-19. Patients and
Methods We assessed the neuropsychiatric disorders associated with COVID-19 in a …