Crocin: A fighter against inflammation and pain

M Hashemzaei, C Mamoulakis, K Tsarouhas… - Food and Chemical …, 2020 - Elsevier
Crocin, a water-soluble carotenoid, is known as a pharmacologically active compound,
particularly for its potent anti-oxidant activity. The present work provides a comprehensive …

Saffron: the golden spice with therapeutic properties on digestive diseases

H Ashktorab, A Soleimani, G Singh, A Amin… - Nutrients, 2019 - mdpi.com
Saffron is a natural compound that has been used for centuries in many parts of the world as
a food colorant and additive. It was shown to have the ability to mitigate various disorders …

In vitro–in vivo evaluation of chitosan-PLGA nanoparticles for potentiated gastric retention and anti-ulcer activity of diosmin

WE Abd El Hady, EA Mohamed… - International journal …, 2019 - Taylor & Francis
Background Diosmin showed poor water solubility and low bioavailability. Poly (d, l-lactide-
co-glycolide)(PLGA) nanoparticles were successfully used to improve the drugs solubility …

Momordica charantia polysaccharides ameliorate oxidative stress, inflammation, and apoptosis in ethanol-induced gastritis in mucosa through NF-kB signaling …

M Raish, A Ahmad, MA Ansari, KM Alkharfy… - International Journal of …, 2018 - Elsevier
This study investigated the therapeutic role of polysaccharides from M. charantia and their
mechanism of action against ethanol-induced gastric ulcers in rats. Their effects were …

Saffron extract and crocin exert anti-inflammatory and anti-oxidative effects in a repetitive mild traumatic brain injury mouse model

M Salem, M Shaheen, A Tabbara, J Borjac - Scientific Reports, 2022 - nature.com
Abstract Saffron Crocus sativus L.(C. sativus) is a flower from the iridaceous family. Crocin,
saffron's major constituent, and saffron have anti-oxidative and anti-inflammatory activities …

Antiinflammatory, Antioxidant, and Immunomodulatory Effects of Crocus sativus L. and its Main Constituents

MH Boskabady, T Farkhondeh - Phytotherapy Research, 2016 - Wiley Online Library
Crocus sativus L.(C. sativus), commonly known as saffron, is used as a food additive,
preservative, and medicinal herb. Traditionally, it has been used as an alternative treatment …

Gastroprotective effect of zingerone on ethanol-induced gastric ulcers in rats

N Sistani Karampour, A Arzi, A Rezaie… - Medicina, 2019 - mdpi.com
Background and objectives: Zingerone is an ingredient of ginger (Zingiber officinale) with
different pharmacological activities. Several studies have investigated the effect of zingerone …

Protective effects of piperine on ethanol-induced gastric mucosa injury by oxidative stress inhibition

Z Duan, S Yu, S Wang, H Deng, L Guo, H Yang, H Xie - Nutrients, 2022 - mdpi.com
Piper nigrum Linnaeus is often used as a treatment for chills, stomach diseases, and other
ailments. Piperine has many biological functions; however, its mechanism for preventing …

Crocin improves renal function by declining Nox‐4, IL‐18, and p53 expression levels in an experimental model of diabetic nephropathy

H Yaribeygi, MT Mohammadi… - Journal of cellular …, 2018 - Wiley Online Library
Oxidative damage, inflammation and apoptosis play significant roles in diabetic
nephropathy. Previous studies demonstrated anti‐inflammatory and anti‐oxidative effects of …

Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitro

X Chang, F Luo, W Jiang, L Zhu, J Gao, H He… - International …, 2015 - Elsevier
Salidroside (Sal) is a traditional Chinese medicine with various pharmacological effects. The
present study aimed to investigate the protective effect of Sal on ethanol-induced acute …