Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

The protooncogene c-fos is rapidly activated after noxious stimuli to express the protein Fos
in spinal dorsal horn neurons that are in the 'correct'locations for nociceptive information …

Abstract c-Fos, the protein of the protooncogene c-fos, has been extensively used as a
marker for the activation of nociceptive neurons in the spinal cord for more than twenty years …

The cancer-related event that is most disruptive to the cancer patient's quality of life is pain.
To begin to define the mechanisms that give rise to cancer pain, we examined the …

Bone cancer pain is common among cancer patients and can have a devastating effect on
their quality of life. A chief problem in designing new therapies for bone cancer pain is that it …

Pain is the cancer related event that is most disruptive to the cancer patient's quality of life.
Although bone cancer pain is one of the most severe and common of the chronic pains that …

Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain
for which there is a lack of effective therapy. During tactile allodynia, activation of the sensory …

Bone cancer pain most commonly occurs when tumors originating in breast, prostate, or
lung metastasize to long bones, spinal vertebrae, and/or pelvis. Primary and metastatic …

Pain is the cancer-related event that is most disruptive to the cancer patient's quality of life.
Although bone cancer pain is one of the most severe and common of the chronic pains that …

Injury to the nerve can produce changes in dorsal horn function and pain. This facilitated
processing may be mediated in part by voltage-sensitive calcium channels. Activation of …