Mitochondria are the main source of reactive oxygen species (ROS) in cells. Early studies
have shown that mitochondrial reactive oxygen species (mROS) are related to the …

Reactive Oxygen Species (ROS) can cause oxidative damage and have been proposed to
be the main cause of aging and age-related diseases including cancer, diabetes and …

The brain is the most complex human organ, consuming more energy than any other tissue
in proportion to its size. It relies heavily on mitochondria to produce energy and is made up …

Mitochondria are quantifiably the most important sources of superoxide (O2●−) and
hydrogen peroxide (H2O2) in mammalian cells. The overproduction of these molecules has …

Mitochondrial superoxide production is an important source of reactive oxygen species in
cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites …

Mitochondrial dysfunction has been proposed to play a pivotal role in neurodegenerative
diseases, including Alzheimer's disease (AD). To address whether mitochondrial …

Mitochondria couple respiration to ATP synthesis through an electrochemical proton
gradient. Proton leak across the inner membrane allows adjustment of the coupling …

Neurodegenerative diseases, a subset of age-driven diseases, have been known to exhibit
increased oxidative stress. The resultant increase in reactive oxygen species (ROS) has …

Maximum life span differences among animal species exceed life span variation achieved
by experimental manipulation by orders of magnitude. The differences in the characteristic …

Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to
their prominent role in energy metabolism, mitochondria are intimately involved in various …