Recent research into structural variants (SVs) has established their importance to medicine
and molecular biology, elucidating their role in various diseases, regulation of gene …

Pan-genomic studies aim at representing the entire sequence diversity within a species to
provide useful resources for evolutionary studies, functional genomics and breeding of …

The colonization of the human gut microbiome begins at birth, and over time, these microbial
communities become increasingly complex. Most of what we currently know about the …

Abstract Comparison of DNA sequences from different species is a fundamental method for
identifying functional elements in genomes. Here, we describe the VISTA family of tools …

This study examines genomic duplications, deletions, and rearrangements that have
happened at scales ranging from a single base to complete chromosomes by comparing the …

Presented here is a genome sequence of an individual human. It was produced from∼ 32
million random DNA fragments, sequenced by Sanger dideoxy technology and assembled …

Introduction During vertebrate limb development, gene members of the HoxD cluster are
transcribed in two subsequent waves, following a collinear strategy. Early on, genes located …

Little is known about the types of mutations underlying the evolution of species-specific
traits. The metal hyperaccumulator Arabidopsis halleri has the rare ability to colonize heavy …

Transcription factor Foxp3 (forkhead box P3), restricted in its expression to a specialized
regulatory CD4+ T-cell subset (TR) with a dedicated suppressor function, controls TR …

Background MicroRNAs (miRNAs) are a large family of 21-22 nucleotide non-coding RNAs
with presumed post-transcriptional regulatory activity. Most miRNAs were identified by direct …