The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

Hepatocellular carcinoma (HCC) currently represents the fifth most common malignancy and
the third-leading cause of cancer-related death worldwide, with incidence and mortality rates …

Abstract Knowledge of cell type composition in disease relevant tissues is an important step
towards the identification of cellular targets of disease. We present MuSiC, a method that …

Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

Single-cell RNA sequencing (scRNA-seq) offers new opportunities to study gene expression
of tens of thousands of single cells simultaneously. We present DeepImpute, a deep neural …

Almost all biomedical research to date has relied upon mean measurements from cell
populations, however it is well established that what it is observed at this macroscopic level …

The recent development of single-cell RNA sequencing has deepened our understanding of
the cell as a functional unit, providing new insights based on gene expression profiles of …

Data normalization is vital to single-cell sequencing, addressing limitations presented by low
input material and various forms of bias or noise present in the sequencing process. Several …

Single-cell RNA sequencing (scRNA-seq) enables the quantification of each gene's
expression distribution across cells, thus allowing the assessment of the dispersion, nonzero …

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a common but
poorly understood form of heart failure, characterized by impaired diastolic function. It is …