Among the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2
hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 …

Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

Abstract Objectives Polyunsaturated fatty acids (PUFAs) are structural components of
membrane phospholipids and precursors of oxygenated lipid mediators with diverse …

The number of double bonds in the acyl chains of membrane lipids varies tremendously at
all scales of life, from the organism level to the subcellular level, where differences in lipid …

Lipid droplets, classically regarded as static storage organelles, are currently considered as
dynamic structures involved in key processes of lipid metabolism, cellular homeostasis and …

During an infection, inflammation mobilizes immune cells to eliminate the pathogen and
protect the host. However, inflammation can be detrimental when exacerbated and/or …

There is currently growing attention being paid to the role of elevated triglycerides (TGs) as
important mediators of residual atherosclerotic cardiovascular disease (ASCVD) risk. This …

Lipidomics is of growing importance for clinical and biomedical research due to many
associations between lipid metabolism and diseases. The discovery of these associations is …

Among the phospholipase A 2 (PLA 2) superfamily, group IVA cytosolic PLA 2 (cPLA 2 α) is
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …

Lipoxygenases (LOX) transform arachidonic acid (AA, C20: 4) and docosahexaenoic acid
(DHA, C22: 6) into bioactive lipid mediators (LMs) that comprise not only pro-inflammatory …