Polymer degradation and drug delivery in PLGA‐based drug–polymer applications: A review of experiments and theories
Y Xu, CS Kim, DM Saylor, D Koo - Journal of biomedical …, 2017 - Wiley Online Library
Poly (lactic‐co‐glycolic acid)(PLGA) copolymers have been broadly used in controlled drug
release applications. Because these polymers are biodegradable, they provide an attractive …
release applications. Because these polymers are biodegradable, they provide an attractive …
Tissue engineering; strategies, tissues, and biomaterials
Current tissue regenerative strategies rely mainly on tissue repair by transplantation of the
synthetic/natural implants. However, limitations of the existing strategies have increased the …
synthetic/natural implants. However, limitations of the existing strategies have increased the …
Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
N Bertrand, P Grenier, M Mahmoudi, EM Lima… - Nature …, 2017 - nature.com
In vitro incubation of nanomaterials with plasma offer insights on biological interactions, but
cannot fully explain the in vivo fate of nanomaterials. Here, we use a library of polymer …
cannot fully explain the in vivo fate of nanomaterials. Here, we use a library of polymer …
Immune system targeting by biodegradable nanoparticles for cancer vaccines
The concept of therapeutic cancer vaccines is based on the activation of the immune system
against tumor cells after the presentation of tumor antigens. Nanoparticles (NPs) have …
against tumor cells after the presentation of tumor antigens. Nanoparticles (NPs) have …
Macromolecular architectures through organocatalysis
In virtue of the rising demand for metal-free polymeric materials, organocatalytic
polymerization has emerged and blossomed unprecedentedly in the past 15 years into an …
polymerization has emerged and blossomed unprecedentedly in the past 15 years into an …
A simple confined impingement jets mixer for flash nanoprecipitation
J Han, Z Zhu, H Qian, AR Wohl, CJ Beaman… - Journal of …, 2012 - Elsevier
ABSTRACT Johnson and Prud′ homme (2003. AICHE J 49: 2264–2282) introduced the
confined impingement jets (CIJ) mixer to prepare nanoparticles loaded with hydrophobic …
confined impingement jets (CIJ) mixer to prepare nanoparticles loaded with hydrophobic …
Polymers from sugars: cyclic monomer synthesis, ring-opening polymerisation, material properties and applications
Plastics are ubiquitous in modern society. However, the reliance on fossil fuels and the
environmental persistence of most polymers make them unsustainable. Scientists are facing …
environmental persistence of most polymers make them unsustainable. Scientists are facing …
Transport of PEGylated-PLA nanoparticles across a blood brain barrier model, entry into neuronal cells and in vivo brain bioavailability
JM Rabanel, PA Piec, S Landri, SA Patten… - Journal of Controlled …, 2020 - Elsevier
Treatments of neurodegenerative diseases (NDDs) are severely hampered by the presence
of the blood-brain barrier (BBB) precluding efficient brain drug delivery. The development of …
of the blood-brain barrier (BBB) precluding efficient brain drug delivery. The development of …
Anti-polyethylene glycol antibodies alter the protein corona deposited on nanoparticles and the physiological pathways regulating their fate in vivo
P Grenier, IM de Oliveira Viana, EM Lima… - Journal of controlled …, 2018 - Elsevier
Multiple studies highlight the strong prevalence of anti-poly (ethylene glycol)(anti-PEG)
antibodies in the general human population. As we develop therapeutic modalities using …
antibodies in the general human population. As we develop therapeutic modalities using …
Flash nanoprecipitation: particle structure and stability
KM Pustulka, AR Wohl, HS Lee, AR Michel… - Molecular …, 2013 - ACS Publications
Flash nanoprecipitation (FNP) is a process that, through rapid mixing, stabilizes an insoluble
low molecular weight compound in a nanosized, polymer-stabilized delivery vehicle. The …
low molecular weight compound in a nanosized, polymer-stabilized delivery vehicle. The …