Polymer degradation and drug delivery in PLGA‐based drug–polymer applications: A review of experiments and theories

Y Xu, CS Kim, DM Saylor, D Koo - Journal of biomedical …, 2017 - Wiley Online Library
Poly (lactic‐co‐glycolic acid)(PLGA) copolymers have been broadly used in controlled drug
release applications. Because these polymers are biodegradable, they provide an attractive …

Tissue engineering; strategies, tissues, and biomaterials

B Bakhshandeh, P Zarrintaj, MO Oftadeh… - Biotechnology and …, 2017 - Taylor & Francis
Current tissue regenerative strategies rely mainly on tissue repair by transplantation of the
synthetic/natural implants. However, limitations of the existing strategies have increased the …

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

N Bertrand, P Grenier, M Mahmoudi, EM Lima… - Nature …, 2017 - nature.com
In vitro incubation of nanomaterials with plasma offer insights on biological interactions, but
cannot fully explain the in vivo fate of nanomaterials. Here, we use a library of polymer …

Immune system targeting by biodegradable nanoparticles for cancer vaccines

JM Silva, M Videira, R Gaspar, V Préat… - Journal of controlled …, 2013 - Elsevier
The concept of therapeutic cancer vaccines is based on the activation of the immune system
against tumor cells after the presentation of tumor antigens. Nanoparticles (NPs) have …

Macromolecular architectures through organocatalysis

S Hu, J Zhao, G Zhang, H Schlaad - Progress in Polymer Science, 2017 - Elsevier
In virtue of the rising demand for metal-free polymeric materials, organocatalytic
polymerization has emerged and blossomed unprecedentedly in the past 15 years into an …

A simple confined impingement jets mixer for flash nanoprecipitation

J Han, Z Zhu, H Qian, AR Wohl, CJ Beaman… - Journal of …, 2012 - Elsevier
ABSTRACT Johnson and Prud′ homme (2003. AICHE J 49: 2264–2282) introduced the
confined impingement jets (CIJ) mixer to prepare nanoparticles loaded with hydrophobic …

Polymers from sugars: cyclic monomer synthesis, ring-opening polymerisation, material properties and applications

GL Gregory, EM López-Vidal, A Buchard - Chemical Communications, 2017 - pubs.rsc.org
Plastics are ubiquitous in modern society. However, the reliance on fossil fuels and the
environmental persistence of most polymers make them unsustainable. Scientists are facing …

Transport of PEGylated-PLA nanoparticles across a blood brain barrier model, entry into neuronal cells and in vivo brain bioavailability

JM Rabanel, PA Piec, S Landri, SA Patten… - Journal of Controlled …, 2020 - Elsevier
Treatments of neurodegenerative diseases (NDDs) are severely hampered by the presence
of the blood-brain barrier (BBB) precluding efficient brain drug delivery. The development of …

Anti-polyethylene glycol antibodies alter the protein corona deposited on nanoparticles and the physiological pathways regulating their fate in vivo

P Grenier, IM de Oliveira Viana, EM Lima… - Journal of controlled …, 2018 - Elsevier
Multiple studies highlight the strong prevalence of anti-poly (ethylene glycol)(anti-PEG)
antibodies in the general human population. As we develop therapeutic modalities using …

Flash nanoprecipitation: particle structure and stability

KM Pustulka, AR Wohl, HS Lee, AR Michel… - Molecular …, 2013 - ACS Publications
Flash nanoprecipitation (FNP) is a process that, through rapid mixing, stabilizes an insoluble
low molecular weight compound in a nanosized, polymer-stabilized delivery vehicle. The …