TGF-β Signaling
K Tzavlaki, A Moustakas - Biomolecules, 2020 - mdpi.com
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …
Signaling receptors for TGF-β family members
CH Heldin, A Moustakas - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes
of type I and type II dual specificity kinase receptors. The activation and stability of the …
of type I and type II dual specificity kinase receptors. The activation and stability of the …
Design of protein-binding proteins from the target structure alone
The design of proteins that bind to a specific site on the surface of a target protein using no
information other than the three-dimensional structure of the target remains a challenge …
information other than the three-dimensional structure of the target remains a challenge …
Structural biology and evolution of the TGF-β family
AP Hinck, TD Mueller… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
We review the evolution and structure of members of the transforming growth factor β (TGF-
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …
Latent TGF-β structure and activation
Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex
with its prodomain. Activation of TGF-β1 requires the binding of αv integrin to an RGD …
with its prodomain. Activation of TGF-β1 requires the binding of αv integrin to an RGD …
TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis
T Sun, Z Huang, WC Liang, J Yin, WY Lin… - Science translational …, 2021 - science.org
Transforming growth factor–β (TGFβ) is a key driver of fibrogenesis. Three TGFβ isoforms
(TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions in embryonic development; …
(TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions in embryonic development; …
Structural insights into BMP receptors: Specificity, activation and inhibition
D Yadin, P Knaus, TD Mueller - Cytokine & growth factor reviews, 2016 - Elsevier
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β
family (TGFβ), which signal through hetero-tetrameric complexes of type I and type II …
family (TGFβ), which signal through hetero-tetrameric complexes of type I and type II …
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells
CJC Johnston, DJ Smyth, RB Kodali, MPJ White… - Nature …, 2017 - nature.com
Helminth parasites defy immune exclusion through sophisticated evasion mechanisms,
including activation of host immunosuppressive regulatory T (Treg) cells. The mouse …
including activation of host immunosuppressive regulatory T (Treg) cells. The mouse …
Biochemistry and biology of GDF11 and myostatin: similarities, differences, and questions for future investigation
RG Walker, T Poggioli, L Katsimpardi… - Circulation …, 2016 - Am Heart Assoc
Growth differentiation factor 11 (GDF11) and myostatin (or GDF8) are closely related
members of the transforming growth factor β superfamily and are often perceived to serve …
members of the transforming growth factor β superfamily and are often perceived to serve …
[HTML][HTML] Structural studies of the TGF-βs and their receptors–insights into evolution of the TGF-β superfamily
AP Hinck - FEBS letters, 2012 - Elsevier
TGF-βs are small secreted signaling proteins that function as vital regulators of cellular
growth and differentiation. They signal through a single pair of receptors, known as TβR-I …
growth and differentiation. They signal through a single pair of receptors, known as TβR-I …