Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Background: Antimicrobial resistance represents a serious threat to human health across the
globe. The cost of bringing a new antibiotic from discovery to market is high and return on …

The increasing emergence and dissemination of multidrug resistant (MDR) bacterial
pathogens accelerate the desires for new antibiotics. Natural products dominate the …

Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …

Unique coumarin aminophosphonates as new antibacterial agents were designed and
synthesized to combat severely bacterial resistance. Bioactivity assessment identified that 3 …

Medicinal plants and their bioactive molecules are integral components of nature and have
supported the health of human societies for millennia. However, the prevailing view of …

Bacterial infections have seriously threatened public health especially with the increasing
resistance and the cliff-like decline of the number of newly approved antibacterial agents …

The metal-polyphenol networks have attracted appealing attention for diverse biomedical
applications due to their remarkable characteristics. Though various of metal-polyphenolic …

Natural berberine-derived azolyl ethanols as new structural antibacterial agents were
designed and synthesized for fighting with dreadful bacterial resistance. Partial target …

The overuse of antibiotics in the past decades has led to the emergence of a large number
of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug …