Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

Any account of “what is special about the human brain”(Passingham 2008) must specify the
neural basis of our unique ability to produce speech and delineate how these remarkable …

The central nervous system controls food consumption to maintain metabolic homoeostasis.
In response to a meal, visceral signals from the gut activate neurons in the nucleus of the …

An inverse relationship between brain serotonin and food intake and body weight has been
known for more than 30years. Specifically, augmentation of brain serotonin inhibits food …

To meet the challenge to human health posed by obesity, a better understanding of the
regulation of feeding is essential. Medications targeting 5-hydroxytryptamine (5-HT; …

Early life stress, in the form of MD (24 h at pnd 9), interferes with brain developmental
trajectories modifying both behavioral and neurobiochemical parameters. MD has been …

Objective Overweight and obesity are endemic in developed countries, with a substantial
negative impact on human health. Medications developed to treat obesity include agonists …

The peptide neurotensin (Nts) was discovered within the brain over 40 years ago and is
implicated in regulating analgesia, body temperature, blood pressure, locomotor activity and …

Brainstem A2/C2 catecholamine (CA) neurons in the solitary tract nucleus (NTS) are thought
to play an important role in the control of food intake and other homeostatic functions. We …

Glucose is a crucial substrate essential for cell survival and function. Changes in glucose
levels impact neuronal activity and glucose deprivation increases feeding. Several brain …