Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …

Tumors have evolved in various mechanisms to evade the immune system, hindering the
antitumor immune response and facilitating tumor progression. Immunotherapy has become …

Hypoxia exerts a profound impact on diverse aspects of cancer biology. Increasing evidence
has revealed novel functions of hypoxia in cancer cell epigenomics, epitranscriptomics …

Currently, cell membrane is always utilized for the construction of biomimetic nanoparticles.
By contrast, mimicking the intracellular activity seems more meaningful. Inspired by the …

Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …

Chronic unresolving inflammation is emerging as a key underlying pathological feature of
many if not most diseases ranging from autoimmune conditions to cardiometabolic and …

Abstract DNMT1 (DNA methyltransferase 1) is the predominant member of the DNMT family
and the most abundant DNMT in various cell types. It functions as a maintenance DNMT and …

Purpose: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting
children and adults. Chemotherapy treatments show high response rates but have …

Simple Summary Immunotherapy aims to engage various immune cells in the elimination of
cancer cells. Neutrophils are the most abundant leukocytes in the circulation and have …