p53 isoforms and their implications in cancer
M Vieler, S Sanyal - Cancers, 2018 - mdpi.com
In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …
p53 amyloid aggregation in cancer: function, mechanism, and therapy
J Li, M Guo, L Chen, Z Chen, Y Fu, Y Chen - Experimental Hematology & …, 2022 - Springer
Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has
been proposed in recent years. p53, the most well-known tumor suppressor, has been …
been proposed in recent years. p53, the most well-known tumor suppressor, has been …
[HTML][HTML] TP53 mutations in epithelial ovarian cancer
Y Zhang, L Cao, D Nguyen, H Lu - Translational cancer research, 2016 - ncbi.nlm.nih.gov
Genomic sequencing analyses of a variety of human cancers have revealed that massive
mutations of cancer-relevant genes are the major alterations in cancerous cells, and their …
mutations of cancer-relevant genes are the major alterations in cancerous cells, and their …
Prion-like aggregation of mutant p53 in cancer
p53 is a master regulatory protein that participates in cellular processes such as apoptosis,
DNA repair, and cell cycle control. p53 functions as a homotetrameric tumor suppressor, and …
DNA repair, and cell cycle control. p53 functions as a homotetrameric tumor suppressor, and …
Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands
EC Petronilho, MM Pedrote, MA Marques… - Chemical …, 2021 - pubs.rsc.org
Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers
inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The …
inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The …
p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis
The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of
human cancers are associated with the loss of p53 functions, where p53 often accumulates …
human cancers are associated with the loss of p53 functions, where p53 often accumulates …
p53 protein aggregation promotes platinum resistance in ovarian cancer
Y Yang-Hartwich, MG Soteras, ZP Lin, J Holmberg… - Oncogene, 2015 - nature.com
High-grade serous ovarian carcinoma (HGSOC), the most lethal gynecological cancer, often
leads to chemoresistant diseases. The p53 protein is a key transcriptional factor regulating …
leads to chemoresistant diseases. The p53 protein is a key transcriptional factor regulating …
The aggregation of mutant p53 produces prion-like properties in cancer
The tumor suppressor protein p53 loses its function in more than 50% of human malignant
tumors. Recent studies have suggested that mutant p53 can form aggregates that are …
tumors. Recent studies have suggested that mutant p53 can form aggregates that are …
Prion-like p53 amyloids in cancer
The global transcription factor, p53, is a master regulator of gene expression in cells.
Mutations in the TP53 gene promote unregulated cell growth through the inactivation of …
Mutations in the TP53 gene promote unregulated cell growth through the inactivation of …
Aggregation and prion-like properties of misfolded tumor suppressors: is cancer a prion disease?
DCF Costa, GAP de Oliveira… - Cold Spring …, 2016 - cshperspectives.cshlp.org
Prion diseases are disorders that share several characteristics that are typical of many
neurodegenerative diseases. Recently, several studies have extended the prion concept to …
neurodegenerative diseases. Recently, several studies have extended the prion concept to …