[HTML][HTML] Wnt/β-catenin signaling, disease, and emerging therapeutic modalities
The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
[HTML][HTML] Wnt/β-catenin signaling and disease
The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …
[HTML][HTML] The inner blood-retinal barrier: Cellular basis and development
M Díaz-Coránguez, C Ramos, DA Antonetti - Vision research, 2017 - Elsevier
The blood-retinal barrier (BRB) regulates transport across retinal capillaries maintaining
proper neural homeostasis and protecting the neural tissue from potential blood borne …
proper neural homeostasis and protecting the neural tissue from potential blood borne …
The molecular basis of human retinal and vitreoretinal diseases
W Berger, B Kloeckener-Gruissem… - Progress in retinal and eye …, 2010 - Elsevier
During the last two to three decades, a large body of work has revealed the molecular basis
of many human disorders, including retinal and vitreoretinal degenerations and …
of many human disorders, including retinal and vitreoretinal degenerations and …
Wnt Signaling in vascular eye diseases
The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …
[HTML][HTML] Familial exudative vitreoretinopathy and related retinopathies
DF Gilmour - Eye, 2015 - nature.com
Familial exudative vitreoretinopathy (FEVR) is a rare inherited disorder of retinal
angiogenesis. Cases can be autosomal dominant, autosomal recessive, or X-linked. FEVR …
angiogenesis. Cases can be autosomal dominant, autosomal recessive, or X-linked. FEVR …
Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood–brain barrier and blood–retina barrier development and maintenance
Y Wang, C Cho, J Williams… - Proceedings of the …, 2018 - National Acad Sciences
β-Catenin signaling controls the development and maintenance of the blood–brain barrier
(BBB) and the blood–retina barrier (BRB), but the division of labor and degree of …
(BBB) and the blood–retina barrier (BRB), but the division of labor and degree of …
Frizzled receptors in development and disease
Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate
canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr …
canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr …
[HTML][HTML] Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling
X Zhu, M Yang, P Zhao, S Li, L Zhang… - The Journal of …, 2021 - Am Soc Clin Investig
Familial exudative vitreoretinopathy (FEVR) is a severe retinal vascular disease that causes
blindness. FEVR has been linked to mutations in several genes associated with inactivation …
blindness. FEVR has been linked to mutations in several genes associated with inactivation …
ZNF408 is mutated in familial exudative vitreoretinopathy and is crucial for the development of zebrafish retinal vasculature
RWJ Collin, K Nikopoulos, M Dona… - Proceedings of the …, 2013 - National Acad Sciences
Familial exudative vitreoretinopathy (FEVR) is a genetically heterogeneous disorder
characterized by abnormal vascularization of the peripheral retina, which can result in retinal …
characterized by abnormal vascularization of the peripheral retina, which can result in retinal …