The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …

The blood-retinal barrier (BRB) regulates transport across retinal capillaries maintaining
proper neural homeostasis and protecting the neural tissue from potential blood borne …

During the last two to three decades, a large body of work has revealed the molecular basis
of many human disorders, including retinal and vitreoretinal degenerations and …

The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …

Familial exudative vitreoretinopathy (FEVR) is a rare inherited disorder of retinal
angiogenesis. Cases can be autosomal dominant, autosomal recessive, or X-linked. FEVR …

β-Catenin signaling controls the development and maintenance of the blood–brain barrier
(BBB) and the blood–retina barrier (BRB), but the division of labor and degree of …

Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate
canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr …

Familial exudative vitreoretinopathy (FEVR) is a severe retinal vascular disease that causes
blindness. FEVR has been linked to mutations in several genes associated with inactivation …

Familial exudative vitreoretinopathy (FEVR) is a genetically heterogeneous disorder
characterized by abnormal vascularization of the peripheral retina, which can result in retinal …