Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

NAFLD and cardiovascular diseases: a clinical review

P Kasper, A Martin, S Lang, F Kuetting… - Clinical research in …, 2021 - Springer
Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic liver disease in
Western countries and affects approximately 25% of the adult population. Since NAFLD is …

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

J Aron-Wisnewsky, C Vigliotti, J Witjes, P Le… - Nature Reviews …, 2020 - nature.com
Gut microbiota dysbiosis has been repeatedly observed in obesity and type 2 diabetes
mellitus, two metabolic diseases strongly intertwined with non-alcoholic fatty liver disease …

Nonalcoholic steatohepatitis: a review

AC Sheka, O Adeyi, J Thompson, B Hameed… - Jama, 2020 - jamanetwork.com
Importance Nonalcoholic steatohepatitis (NASH) is the inflammatory subtype of nonalcoholic
fatty liver disease (NAFLD) and is associated with disease progression, development of …

Adverse effects of statin therapy: perception vs. the evidence–focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract

F Mach, KK Ray, O Wiklund, A Corsini… - European heart …, 2018 - academic.oup.com
Aims To objectively appraise evidence for possible adverse effects of long-term statin
therapy on glucose homeostasis, cognitive, renal and hepatic function, and risk for …

Non-alcoholic fatty liver disease and dyslipidemia: an update

N Katsiki, DP Mikhailidis, CS Mantzoros - Metabolism, 2016 - Elsevier
Non-alcoholic fatty liver (NAFLD) is the most common liver disease worldwide, progressing
from simple steatosis to necroinflammation and fibrosis (leading to non-alcoholic …

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

Y Rotman, AJ Sanyal - Gut, 2017 - gut.bmj.com
Given the high prevalence and rising incidence of non-alcoholic fatty liver disease (NAFLD),
the absence of approved therapies is striking. Although the mainstay of treatment of NAFLD …

[HTML][HTML] KASL clinical practice guidelines: management of nonalcoholic fatty liver disease

SH Kang, HW Lee, JJ Yoo, Y Cho, SU Kim… - Clinical and …, 2021 - ncbi.nlm.nih.gov
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide
as the obese and diabetic populations increase, and it has been estimated to be 20–30% in …

Nonalcoholic fatty liver disease and fibrosis associated with increased risk of cardiovascular events in a prospective study

F Baratta, D Pastori, F Angelico, A Balla… - Clinical …, 2020 - Elsevier
Background & Aims Patients with non-alcoholic fatty liver disease (NAFLD) are at increased
chance for cardiovascular events (CVEs). Severity of liver fibrosis is used to determine …

Therapies in non‐alcoholic steatohepatitis (NASH)

AM Oseini, AJ Sanyal - Liver International, 2017 - Wiley Online Library
The hallmark of non‐alcoholic fatty liver disease (NAFLD) is excessive fatty accumulation in
the hepatocytes, which may be an isolated event (non‐alcoholic fatty liver, NAFL) or …