The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

Within the growing field of amino acid metabolism, tryptophan (Trp) catabolism is an area of
increasing interest. Trp is essential for protein synthesis, and its metabolism gives rise to …

Inflammatory bowel disease (IBD) is a complex multi-factorial disease for which
physiologically relevant in vitro models are lacking. Existing models are often a compromise …

Pressure-overloaded left ventricular remodeling in young population is progressive and
readily degenerate into heart failure. The aims of this study were to identify a plasma …

Tumors display increased uptake and processing of nutrients to fulfill the demands of rapidly
proliferating cancer cells. Seminal studies have shown that the proto-oncogene MYC …

The cancer-immunity cycle (CIC) comprises a series of events that are required for immune-
mediated control of tumor growth. Interruption of one or more steps of the CIC enables …

With high prevalence and mortality, together with metabolic reprogramming, colorectal
cancer is a leading cause of cancer-related death. Metabolic reprogramming gives tumors …

Background While regulated WNT activity is required for normal development and stem cell
maintenance, mutations that lead to constitutive activation of the WNT pathway cause …

Many studies have focused on understanding the regulation and functions of aberrant
protein synthesis in colorectal cancer (CRC), leaving the ribosome, its main effector …

The global burden of colorectal cancer (CRC) is expected to continuously increase. Through
research performed in the past decades, the effects of various environmental factors on CRC …