Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …

There are several interactions within the tumor microenvironment (TME) that affect the
response of cancer cells to therapy. There are also a large number of cells and secretions in …

Microtubule proteins form a dynamic component of the cytoskeleton, and play key roles in
cellular processes, such as vesicular transport, cell motility and mitosis. Expression of …

Background Environment inside even a small tumor is characterized by total (anoxia) or
partial oxygen deprivation,(hypoxia). It has been shown that radiotherapy and some …

The notch signalling pathway is involved in differentiation, proliferation, angiogenesis,
vascular remodelling, and apoptosis. Deregulated expression of notch receptors, ligands …

Introduction: βIII-Tubulin (TUBB3) is predominantly expressed in neurons of the central and
peripheral nervous systems, while in normal non-neoplastic tissues it is barely detectable …

Abstract MicroRNA-210-3p is the most prominent hypoxia regulated microRNA, and it has
been found significantly overexpressed in different human cancers. We performed the …

Taxanes are chemotherapeutic drugs employed in the clinic to treat a variety of
malignancies. Despite their overall efficacy, cancer cells often display resistance to taxanes …

Drug development for castration resistant prostate cancer (CRPC) is challenging, since this
cancer is still associated with high mortality and limited therapeutic options. In 2004 …

Background: βIII-Tubulin, encoded by the TUBB3 gene, is a microtubule protein. Several
studies have shown that overexpression of TUBB3 is linked to poor prognosis and is …