Heat shock proteins and cancer

J Wu, T Liu, Z Rios, Q Mei, X Lin, S Cao - Trends in pharmacological …, 2017 - cell.com
Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding
and maturation whose expression is induced by heat shock or other stressors. The major …

Surviving stress: modulation of ATF4-mediated stress responses in normal and malignant cells

IMN Wortel, LT van der Meer, MS Kilberg… - Trends in Endocrinology …, 2017 - cell.com
Activating transcription factor 4 (ATF4) is a stress-induced transcription factor that is
frequently upregulated in cancer cells. ATF4 controls the expression of a wide range of …

The role of the PERK/eIF2α/ATF4/CHOP signaling pathway in tumor progression during endoplasmic reticulum stress

W Rozpedek, D Pytel, B Mucha… - Current molecular …, 2016 - ingentaconnect.com
Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with
rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond …

Endoplasmic reticulum stress and the hallmarks of cancer

H Urra, E Dufey, T Avril, E Chevet, C Hetz - Trends in cancer, 2016 - cell.com
Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis,
thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an …

The role of endoplasmic reticulum stress in human pathology

SA Oakes, FR Papa - Annual Review of Pathology: Mechanisms …, 2015 - annualreviews.org
Numerous genetic and environmental insults impede the ability of cells to properly fold and
posttranslationally modify secretory and transmembrane proteins in the endoplasmic …

Targeting the unfolded protein response in disease

C Hetz, E Chevet, HP Harding - Nature reviews Drug discovery, 2013 - nature.com
Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is a feature of specialized secretory cells and is also observed in many diseases, including …

Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

AS Lee - Nature Reviews Cancer, 2014 - nature.com
The glucose-regulated proteins (GRPs) are stress-inducible chaperones that mostly reside
in the endoplasmic reticulum or the mitochondria. Recent advances show that the GRPs …

Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration

R Bravo, V Parra, D Gatica, AE Rodriguez… - International review of …, 2013 - Elsevier
The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective …

JM Axten, JR Medina, Y Feng, A Shu… - Journal of medicinal …, 2012 - ACS Publications
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response
to a variety of endoplasmic reticulum stresses implicated in numerous disease states …

Restoration of the immunogenicity of tumor cells for enhanced cancer therapy via nanoparticle‐mediated copper chaperone inhibition

F Ding, F Li, D Tang, B Wang, J Liu… - Angewandte Chemie …, 2022 - Wiley Online Library
Recent progress in studying copper‐dependent targets and pathways in the context of tumor
treatment has provided new insights into therapeutic strategies of leveraging copper …