[HTML][HTML] Molecular mechanisms and therapeutic targets for diabetic kidney disease

KR Tuttle, R Agarwal, CE Alpers, GL Bakris… - Kidney international, 2022 - Elsevier
Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …

Sarcopenia in chronic kidney disease: what have we learned so far?

A Sabatino, L Cuppari, P Stenvinkel, B Lindholm… - Journal of …, 2021 - Springer
The term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of
muscle loss that occurs in the elderly. Since then, a broader definition comprising not only …

The gut microbiota (microbiome) in cardiovascular disease and its therapeutic regulation

MM Rahman, F Islam, MH -Or-Rashid… - Frontiers in cellular …, 2022 - frontiersin.org
In the last two decades, considerable interest has been shown in understanding the
development of the gut microbiota and its internal and external effects on the intestine, as …

The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

H Zhu, C Cao, Z Wu, H Zhang, Z Sun, M Wang, H Xu… - Cell metabolism, 2021 - cell.com
The relationship between gut microbial dysbiosis and acute or chronic kidney disease
(CKD) is still unclear. Here, we show that oral administration of the probiotic Lactobacillus …

Inflammation‐related mechanisms in chronic kidney disease prediction, progression, and outcome

S Mihai, E Codrici, ID Popescu… - Journal of …, 2018 - Wiley Online Library
Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …

The impact of CKD on uremic toxins and gut microbiota

J Rysz, B Franczyk, J Ławiński, R Olszewski… - Toxins, 2021 - mdpi.com
Numerous studies have indicated that the progression of chronic kidney disease (CKD) to
end-stage renal disease (ESRD) is strictly associated with the accumulation of toxic …

Creatinine: from physiology to clinical application

K Kashani, MH Rosner, M Ostermann - European journal of internal …, 2020 - Elsevier
Estimating static kidney function accurately and detecting changes in kidney function in a
timely fashion are challenging but critically important tasks. Serum creatinine is the most …

Microbiome–metabolome reveals the contribution of gut–kidney axis on kidney disease

YY Chen, DQ Chen, L Chen, JR Liu, ND Vaziri… - Journal of translational …, 2019 - Springer
Dysbiosis represents changes in composition and structure of the gut microbiome
community (microbiome), which may dictate the physiological phenotype (health or …

ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities–role of gut microbiota dysbiosis

SD Viana, S Nunes, F Reis - Ageing research reviews, 2020 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) is a pandemic condition caused by the new
coronavirus SARS-CoV-2. The typical symptoms are fever, cough, shortness of breath …

Inulin fructans in diet: Role in gut homeostasis, immunity, health outcomes and potential therapeutics

MM Tawfick, H Xie, C Zhao, P Shao… - International Journal of …, 2022 - Elsevier
Inulin consumption in both humans and animal models is recognized for its prebiotic action
with the most consistent change that lies in enhancing the growth and functionality of …