A modern approach to dyslipidemia

AJ Berberich, RA Hegele - Endocrine reviews, 2022 - academic.oup.com
Lipid disorders involving derangements in serum cholesterol, triglycerides, or both are
commonly encountered in clinical practice and often have implications for cardiovascular …

[HTML][HTML] Beyond statins: New pharmacological targets to decrease LDL-cholesterol and cardiovascular events

E Raschi, M Casula, AFG Cicero, A Corsini… - Pharmacology & …, 2023 - Elsevier
The pharmacological treatment of dyslipidemia, a major modifiable risk factor for developing
atherosclerotic cardiovascular disease (ASCVD), remains a debated and controversial …

Bempedoic acid: for whom and when

M Ruscica, CR Sirtori, S Carugo, M Banach… - Current Atherosclerosis …, 2022 - Springer
Abstract Purpose of Review The aim of creating an orally active non-statin cholesterol-
lowering drug was achieved with bempedoic acid, a small linear molecule providing both a …

Lipid lowering therapy: an era beyond statins

T Abdul-Rahman, SMA Bukhari, EC Herrera… - Current problems in …, 2022 - Elsevier
Dyslipidemia, specifically elevated low-density lipoprotein (LDL) cholesterol levels, causes
atherosclerotic cardiovascular disease (ASCVD) and increases the risk of myocardial …

Existing and emerging strategies to lower Lipoprotein (a)

GG Schwartz, CM Ballantyne - Atherosclerosis, 2022 - Elsevier
Abundant evidence links elevated levels of lipoprotein (a)(Lp (a)) to higher cardiovascular
risk, leaving clinicians with the challenge of what measures to take to mitigate Lp (a) …

Advances in treatment of dyslipidemia

J Dybiec, W Baran, B Dąbek, P Fularski… - International Journal of …, 2023 - mdpi.com
Dyslipidemias have emerged as prevalent disorders among patients, posing significant risks
for the development and progression of cardiovascular diseases. These conditions are …

Mechanism of action and therapeutic use of bempedoic acid in atherosclerosis and metabolic syndrome

G Biolo, P Vinci, A Mangogna, M Landolfo… - Frontiers in …, 2022 - frontiersin.org
Bempedoic acid is a new cholesterol-lowering drug, which has recently received US FDA
and EMA approval. This drug targets lipid and glucose metabolism as well as inflammation …

Management of dyslipidemia in patients with non-alcoholic fatty liver disease

A Martin, S Lang, T Goeser, M Demir… - Current atherosclerosis …, 2022 - Springer
Abstract Purpose of Review Patients with non-alcoholic fatty liver disease (NAFLD), often
considered as the hepatic manifestation of the metabolic syndrome, represent a population …

Dyslipidemia and cardiovascular disease: current knowledge, existing challenges, and new opportunities for management strategies

Z Du, Y Qin - Journal of Clinical Medicine, 2023 - mdpi.com
Cardiovascular disease is the leading cause of morbidity and mortality worldwide, and
dyslipidemia is one of the major risk factors. Hypercholesterolemia is the most common form …

[HTML][HTML] Regulation of protein prenylation

D Jung, HS Bachmann - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Prenyltransferases (PTases) are known to play a role in embryonic development, normal
tissue homeostasis and cancer by posttranslationally modifying proteins involved in these …