The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

Stromal cells in adult bone marrow that express leptin receptor (LEPR) are a critical source
of growth factors, including stem cell factor (SCF), for the maintenance of haematopoietic …

Hematopoietic stem cell (HSC) self-renewal and aging are tightly regulated by paracrine
factors from the bone marrow niche. However, whether HSC rejuvenation could be achieved …

Haematopoietic ageing is marked by a loss of regenerative capacity and skewed
differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production …

Decline in hematopoietic stem cell (HSC) function with age underlies limited health span of
our blood and immune systems. In order to preserve health into older age, it is necessary to …

Aging of hematopoietic stem cells (HSCs) is associated with a decline in their regenerative
capacity and multilineage differentiation potential, contributing to the development of blood …

Abstract Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …

Myeloid cells are a major cellular compartment of the immune system comprising
monocytes, dendritic cells, tissue macrophages, and granulocytes. Models of cellular …

Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-
autonomous process, which is the focus of another review in the same issue of …