Ferroptosis: machinery and regulation

X Chen, J Li, R Kang, DJ Klionsky, D Tang - Autophagy, 2021 - Taylor & Francis
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

M Jakaria, AA Belaidi, AI Bush… - Journal of …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

[HTML][HTML] Role and mechanism of ferroptosis in neurological diseases

M Ou, Y Jiang, Y Ji, Q Zhou, Z Du, H Zhu, Z Zhou - Molecular Metabolism, 2022 - Elsevier
Background Ferroptosis, as a new form of cell death, is different from other cell deaths such
as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of …

Traditional uses, phytochemistry, pharmacology, applications, and quality control of Gastrodia elata Blume: a comprehensive review

M Gong, F Lai, J Chen, X Li, Y Chen, Y He - Journal of Ethnopharmacology, 2024 - Elsevier
Abstract Ethnopharmacological relevance Gastrodia elata Blume (G. elata) has a long
historical application in Asian countries and its tubers, seeds, and stalks are capable of …

Recent progress on targeting ferroptosis for cancer therapy

G Xu, H Wang, X Li, R Huang, L Luo - Biochemical Pharmacology, 2021 - Elsevier
Ferroptosis is a new mode of cell death different from cell necrosis, autophagy, apoptosis,
and pyroptosis, which depends on the accumulation of reactive oxygen species (ROS) …

Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4

S Wang, W Liu, J Wang, X Bai - Life Sciences, 2020 - Elsevier
Curculigoside (CUR) is natural ingredient from Curculigo orchioides Gaertn with multiple
biological activities. However, whether CUR protects from ulcerative colitis (UC) and …

Mitochondrial dysfunction promotes aquaporin expression that controls hydrogen peroxide permeability and ferroptosis

Y Takashi, K Tomita, Y Kuwahara… - Free Radical Biology …, 2020 - Elsevier
Most anti-cancer agents and radiotherapy exert their therapeutic effects via the production of
free radicals. Ferroptosis is a recently described cell death process that is accompanied by …

Protective effects of Salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathway

Y Shen, X Shen, S Wang, Y Zhang, Y Wang… - International …, 2022 - Elsevier
Accumulating evidence has highlighted the role of ferroptosis, a novel type of programmed
cell death involved in the pathological process of myocardial infarction (MI). However, the …

Toward improved human health: Nrf2 plays a critical role in regulating ferroptosis

J Lu, Y Zhao, M Liu, J Lu, S Guan - Food & Function, 2021 - pubs.rsc.org
Ferroptosis is a recently defined type of regulated cell death caused by an excess iron-
dependent accumulation of lipid peroxides and is morphologically and biochemically distinct …

[HTML][HTML] Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial …

D Li, G Zhang, Z Wang, J Guo, Y Liu, Y Lu, Z Qin… - European journal of …, 2023 - Elsevier
Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. As a type of
CVDs, myocardial infarction (MI) induces ischemia hypoxia, which leads to excessive …