Our forefathers in pathology, on observing cancer tissue under the microscope in the mid-
19th century, noticed the similarity between embryonic tissue and cancer, and suggested …

Mouse embryonal carcinoma (EC) cells, also called teratocarcinoma stem cells, are
nonpermissive for polyomavirus growth, whereas differentiated derivatives of the cells are …

Neurotransmitter regulation of bone metabolism has been the subject of increasing interest
and investigation. Because serotonin (5-HT) plays a role as a regulator of craniofacial …

A biological reporter gene assay was employed to determine the crucial parameters for
maximizing selective targeting of a Ha-ras codon 12 point mutation (G—-T) using …

We have previously identified a protein factor, PEBP2 (polyomavirus enhancer-binding
protein), in the nuclear extract from mouse NIH 3T3 cells which binds to the sequence motif …

Previous studies suggest that the Epstein-Barr virus nuclear antigen EBNA2 participates in
the regulation of the expression of the viral latent membrane protein (LMP). We have used …

Estrogen is a mitogen for the rat uterus, where it induces transient activation of c-fos and c-
myc protooncogene expression, followed by increases in DNA synthesis and cell …

Gene transcription can be controlled by positive or negative regulatory mechanisms; a
combination of both is frequently responsible for the observed expression patterns. Analysis …

We have found that the activity of the transcription factor PEA3 is regulated by the
expression of non‐nuclear oncogenes. This factor, although distinct from PEA1 (AP1), is …

Cancers arise from stem cells in adult tissues and the cells that make up a cancer reflect the
same stem cell→ progeny→ differentiation progression observed in normal tissues. All adult …