[HTML][HTML] Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models

S Proença, BI Escher, FC Fischer, C Fisher, S Grégoire… - Toxicology in Vitro, 2021 - Elsevier
Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …

Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids

W Cheng, X Li, Y Zhou, H Yu, Y Xie, H Guo… - Science of The Total …, 2022 - Elsevier
Microplastic particles (MP) has been detected in the environment widespread. Human
beings are inevitably exposed to MP via multiple routines. However, the hazard …

Digital twins for tissue culture techniques—concepts, expectations, and state of the art

J Möller, R Pörtner - Processes, 2021 - mdpi.com
Techniques to provide in vitro tissue culture have undergone significant changes during the
last decades, and current applications involve interactions of cells and organoids, three …

In Vitro and In Vivo Toxicity and Biodistribution of Paclitaxel-Loaded Cubosomes as a Drug Delivery Nanocarrier: A Case Study Using an A431 Skin Cancer …

J Zhai, FH Tan, RB Luwor… - ACS Applied Bio …, 2020 - ACS Publications
Cubosomes with an internal three-dimensional (3D) periodic and porous particulate
nanostructure have emerged as a promising drug delivery system for hydrophobic small …

3D human liver spheroids for translational pharmacology and toxicology

M Ingelman‐Sundberg… - Basic & clinical …, 2022 - Wiley Online Library
Drug development is a failure‐prone endeavour, and more than 85% of drugs fail during
clinical development, showcasing that current preclinical systems for compound selection …

Chirality-enhanced transport and drug delivery of graphene nanocarriers to tumor-like cellular spheroid

H Jeon, R Zhu, G Kim, Y Wang - Frontiers in Chemistry, 2023 - frontiersin.org
Chirality, defined as “a mirror image,” is a universal geometry of biological and nonbiological
forms of matter. This geometry of molecules determines how they interact during their …

The end-to-end molecular communication model of extracellular vesicle-based drug delivery

HK Rudsari, M Zoofaghari, M Veletić… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
A closer look at nature has recently brought more interest in exploring and utilizing intra-
body communication networks composed of cells as intrinsic, perfectly biocompatible …

Fabrication of cell spheroids for 3D cell culture and biomedical applications

SY Park, HJ Hong, HJ Lee - BioChip Journal, 2023 - Springer
The significance of 3D cell culture—ie, the maintenance of cell characteristics by mimicking
the natural environment—has been increasing, and various 3D cell culture methods have …

A similarity scaling approach for organ-on-chip devices

JJ Feng, S Hedtrich - Lab on a Chip, 2022 - pubs.rsc.org
Organ-on-chip devices (OoCs) provide more nuanced insights into (patho) physiological
processes of the human body than static tissue models, and are currently the most promising …

Spheroidal Molecular Communication via Diffusion: Signaling Between Homogeneous Cell Aggregates

M Rezaei, H Arjmandi, M Zoofaghari… - … , Biological and Multi …, 2024 - ieeexplore.ieee.org
Recent molecular communication (MC) research has integrated more detailed
computational models to capture the dynamics of practical biophysical systems. This paper …