[HTML][HTML] Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models
Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …
Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids
W Cheng, X Li, Y Zhou, H Yu, Y Xie, H Guo… - Science of The Total …, 2022 - Elsevier
Microplastic particles (MP) has been detected in the environment widespread. Human
beings are inevitably exposed to MP via multiple routines. However, the hazard …
beings are inevitably exposed to MP via multiple routines. However, the hazard …
Digital twins for tissue culture techniques—concepts, expectations, and state of the art
Techniques to provide in vitro tissue culture have undergone significant changes during the
last decades, and current applications involve interactions of cells and organoids, three …
last decades, and current applications involve interactions of cells and organoids, three …
In Vitro and In Vivo Toxicity and Biodistribution of Paclitaxel-Loaded Cubosomes as a Drug Delivery Nanocarrier: A Case Study Using an A431 Skin Cancer …
J Zhai, FH Tan, RB Luwor… - ACS Applied Bio …, 2020 - ACS Publications
Cubosomes with an internal three-dimensional (3D) periodic and porous particulate
nanostructure have emerged as a promising drug delivery system for hydrophobic small …
nanostructure have emerged as a promising drug delivery system for hydrophobic small …
3D human liver spheroids for translational pharmacology and toxicology
M Ingelman‐Sundberg… - Basic & clinical …, 2022 - Wiley Online Library
Drug development is a failure‐prone endeavour, and more than 85% of drugs fail during
clinical development, showcasing that current preclinical systems for compound selection …
clinical development, showcasing that current preclinical systems for compound selection …
Chirality-enhanced transport and drug delivery of graphene nanocarriers to tumor-like cellular spheroid
Chirality, defined as “a mirror image,” is a universal geometry of biological and nonbiological
forms of matter. This geometry of molecules determines how they interact during their …
forms of matter. This geometry of molecules determines how they interact during their …
The end-to-end molecular communication model of extracellular vesicle-based drug delivery
A closer look at nature has recently brought more interest in exploring and utilizing intra-
body communication networks composed of cells as intrinsic, perfectly biocompatible …
body communication networks composed of cells as intrinsic, perfectly biocompatible …
Fabrication of cell spheroids for 3D cell culture and biomedical applications
SY Park, HJ Hong, HJ Lee - BioChip Journal, 2023 - Springer
The significance of 3D cell culture—ie, the maintenance of cell characteristics by mimicking
the natural environment—has been increasing, and various 3D cell culture methods have …
the natural environment—has been increasing, and various 3D cell culture methods have …
A similarity scaling approach for organ-on-chip devices
JJ Feng, S Hedtrich - Lab on a Chip, 2022 - pubs.rsc.org
Organ-on-chip devices (OoCs) provide more nuanced insights into (patho) physiological
processes of the human body than static tissue models, and are currently the most promising …
processes of the human body than static tissue models, and are currently the most promising …
Spheroidal Molecular Communication via Diffusion: Signaling Between Homogeneous Cell Aggregates
Recent molecular communication (MC) research has integrated more detailed
computational models to capture the dynamics of practical biophysical systems. This paper …
computational models to capture the dynamics of practical biophysical systems. This paper …