Highlights•Advances in the combination of the CuAAC reaction with direct screening.•Before
library assembly, the bioisosteric potential of 1, 2, 3-triazole should be confirmed.•The …

The kinesin class of microtubule-associated motor proteins present attractive anticancer
targets owing to their roles in key functions in dividing cells. Two interpolar mitotic kinesins …

Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment
of centrosomes, a state referred to as centrosome amplification (CA). CA can drive …

A chemoenzymatic approach was developed and optimized for the synthesis of a range of N-
protected nonnatural l-and d-biarylalanine derivatives. Starting from 4-bromocinnamic acid …

Centrosome amplification (CA) is a hallmark of cancer that is strongly associated with highly
aggressive disease and worse clinical outcome. Clustering extra centrosomes is a major …

Kinesin motors play diverse roles in mitosis and are targets for antimitotic drugs. The clinical
significance of these motors emphasizes the importance of understanding the molecular …

We herein describe the development and application of a modular technology platform
which incorporates recent advances in plate-based microscale chemistry, automated …

The kinesin motor KIFC1 has been suggested as a potential chemotherapy target due to its
critical role in clustering of the multiple centrosomes found in cancer cells. In this regard …

Introduction: In recent years, a variety of new synthetic methodologies and concepts have
been proposed in the search for new pharmaceutical lead structures and optimization …

Background The kinesin family member C1 (KIFC1, also known as HSET) is a kinesin
superfamily protein (KIFs). Although KIFC1 acts as a crucial role in the development of …