The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

The study of Alzheimer's Disease (AD) has traditionally focused on neuropathological
mechanisms that has guided therapies that attenuate neuropathological features. A new …

Path integration is a spatial navigation ability that requires the integration of information
derived from self-motion cues and stable landmarks, when available, to return to a previous …

Whenever we navigate through different contexts, we build a cognitive map: an internal
representation of the territory. Spatial navigation is a complex skill that involves multiple …

The extracellular potassium ion concentration in the brain exerts a significant influence on
cellular excitability and intercellular communication. Perturbations in the extracellular …

Converging evidence from human and rodent studies suggests that disrupted grid cell
coding in the medial entorhinal cortex (MEC) underlies path integration behavioral deficits …

Progressive cognitive decline in Alzheimer's disease could either be caused by a spreading
molecular pathology or by an initially focal pathology that causes aberrant neuronal activity …

Vitrification is an important assisted reproductive technology, although it induces
mitochondrial dysfunction in embryos. Herein, we aimed to investigate whether age …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by memory
loss and progressive cognitive impairments. In mouse models of AD pathology, studies have …

Oscillations in neural activity are widespread throughout the brain and can be observed at
the population level through the local field potential. These rhythmic patterns are associated …