Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

In the last few decades, many pathogenic or likely pathogenic genetic mutations in over
hundred different genes have been described for non-ischemic, genetic cardiomyopathies …

The extensive crosstalk between the developing heart and lung is critical to their proper
morphogenesis and maturation. However, there remains a lack of models that investigate …

A comprehensive understanding of the pathophysiology and cellular responses to drugs in
human heart disease is limited by species differences between humans and experimental …

Hypoplastic left heart syndrome (HLHS) is a clinically and anatomically severe form of
congenital heart disease (CHD). Although prior studies suggest that HLHS has a complex …

Hypoplastic left heart syndrome (HLHS) is a clinically and anatomically severe form of
congenital heart disease; however, its etiology remains largely unknown. We previously …

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSCs) have received
increasing attention for their clinical use. Many protocols induce cardiomyocytes at an initial …

Cardiac lineage specification in the mouse is controlled by TGFβ and WNT signaling. From
fly to fish, BMP has been identified as an indispensable heart inducer. A detailed analysis of …

Regeneration of insulin-producing cells (IPCs) from induced pluripotent stem cells (iPSCs)
under controlled conditions has a lot of promise to emulate the pancreatic mechanism in …

Background Cardiomyocytes differentiated from human pluripotent stem cells can serve as
an unexhausted source for a cellular cardiac disease model. Although small molecule …