The perception of the Z-disc in striated muscle has undergone significant changes in the
past decade. Traditionally, the Z-disc has been viewed as a passive constituent of the …

During the last 15 years, the perception of the cardiac z-disc has undergone substantial
changes. Initially viewed as a structural component at the lateral boundaries of the …

Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …

The immunosuppressive action of the calcineurin inhibitor cyclosporine A (CsA) stems from
the inhibition of nuclear factor of activated T cells (NFAT) signaling in T cells. CsA is also …

The Rho family of small GTPases (RhoA, Rac1 and Cdc42) controls signal-transduction
pathways that influence many aspects of cell behaviour, including cytoskeletal dynamics,,. At …

Age-related cognitive decline occurs without frank neurodegeneration and is the most
common cause of memory impairment in aging individuals. With increasing longevity …

The actin-based foot processes of kidney podocytes and the interposed slit diaphragm form
the final barrier to proteinuria. Mutations affecting several podocyte proteins cause …

The increased cap-independent translation of anti-apoptotic proteins is involved in the
development of drug resistance in lung cancer but signalling events regulating this are …

Initially identified as an actin-binding protein containing a PSD95-DLG-ZO1 Domain (PZD
domain), Synaptopodin 2 (SYNPO2) has long been considered a structural protein …

Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein
loss. There is mounting evidence that SD proteins also participate in intracellular signaling …