Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently
The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …
ability to modify the sequence, and hence the structure and activity, of individual proteins in …
Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function
Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …
The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota
Fusobacterium nucleatum (Fn) is a dominant bacterial species in colorectal cancer (CRC)
tissue that is associated with cancer progression and poorer patient prognosis. Following a …
tissue that is associated with cancer progression and poorer patient prognosis. Following a …
Microbial enzymes of use in industry
X Liu, C Kokare - Biotechnology of microbial enzymes, 2023 - Elsevier
Many microorganisms produce potent biocatalysts as enzymes that vary in microbial
sources, chemical properties, and mechanisms. Usually, microbial enzymes catalyze the …
sources, chemical properties, and mechanisms. Usually, microbial enzymes catalyze the …
Edible Filamentous Fungi from the Species Monascus: Early Traditional Fermentations, Modern Molecular Biology, and Future Genomics
W Chen, Y He, Y Zhou, Y Shao, Y Feng… - … Reviews in Food …, 2015 - Wiley Online Library
Monascus spp. are filamentous fungi famous for their fermented products, especially red
mold rice (RMR), a traditional fermented food in East Asian areas with a very long edible …
mold rice (RMR), a traditional fermented food in East Asian areas with a very long edible …
A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion
SJB Mallinson, MM Machovina, RL Silveira… - Nature …, 2018 - nature.com
Microbial aromatic catabolism offers a promising approach to convert lignin, a vast source of
renewable carbon, into useful products. Aryl-O-demethylation is an essential biochemical …
renewable carbon, into useful products. Aryl-O-demethylation is an essential biochemical …
Fungal cytochrome p450 monooxygenases: their distribution, structure, functions, family expansion, and evolutionary origin
W Chen, MK Lee, C Jefcoate, SC Kim… - Genome biology and …, 2014 - academic.oup.com
Cytochrome P450 (CYP) monooxygenase superfamily contributes a broad array of
biological functions in living organisms. In fungi, CYPs play diverse and pivotal roles in …
biological functions in living organisms. In fungi, CYPs play diverse and pivotal roles in …
Key fungal degradation patterns, enzymes and their applications for the removal of aliphatic hydrocarbons in polluted soils: A review
C Daccò, C Girometta, MD Asemoloye… - International …, 2020 - Elsevier
Many saturated or unsaturated aliphatic hydrocarbons in fuels and their derivate pose
considerable hazards to biological receptors due to the formation of toxic and carcinogenic …
considerable hazards to biological receptors due to the formation of toxic and carcinogenic …
Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum
Background Many species belonging to the genus Colletotrichum cause anthracnose
disease on a wide range of plant species. In addition to their economic impact, the genus …
disease on a wide range of plant species. In addition to their economic impact, the genus …
Genomic Characterization Reveals Insights Into Patulin Biosynthesis and Pathogenicity in Penicillium Species
B Li, Y Zong, Z Du, Y Chen, Z Zhang… - Molecular Plant …, 2015 - Am Phytopath Society
Penicillium species are fungal pathogens that infect crop plants worldwide. P. expansum
differs from P. italicum and P. digitatum, all major postharvest pathogens of pome and citrus …
differs from P. italicum and P. digitatum, all major postharvest pathogens of pome and citrus …