The process of uncontrolled internal scarring, called fibrosis, is now emerging as a
pathological feature shared by both peripheral and central nervous system diseases. In the …

Protein phosphatases are major regulators of signal transduction and they are involved in
key cellular mechanisms such as proliferation, differentiation, and cell survival. Here we …

Today, neurodegenerative disorders like Alzheimer's disease (AD), Parkinson's disease
(PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) affect millions …

The extracellular matrix of the central nervous system is an interconnected network of
proteins and sugars. It is crucial for homeostasis, but its remodeling in neurological diseases …

Exosomes can pass through the blood-brain barrier and are present in the cerebrospinal
fluid (CSF). The components in exosomes, such as DNA, RNA, protein, and lipids, change …

Fibrosis is defined as the thickening and scarring of connective tissue, usually as a
consequence of tissue damage. The central nervous system (CNS) is special in the sense …

The neural extracellular matrix (ECM) composition shapes the neuronal microenvironment
and undergoes substantial changes upon development and aging, but also due to cerebral …

Metabolic diseases such as obesity and type 2 diabetes are marked by insulin resistance,.
Cells within the arcuate nucleus of the hypothalamus (ARC), which are crucial for regulating …

Plasma proteome composition reflects the inflammatory and metabolic state of the organism
and can be predictive of system-level and organ-specific pathologies. Circulating protein …

Introduction ALS is a fatal neurodegenerative disease for which underlying mechanisms are
incompletely understood. The motor neuron is a central player in ALS pathogenesis but …