Medullary thyroid carcinoma (MTC) is a rare type of tumor that originates from thyroid C cells
and accounts for 2–4% of all malignant thyroid neoplasms. MTC may occur sporadically or …

Multiple endocrine neoplasias are rare hereditary syndromes some of them with malignant
potential. Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary …

This review of the familial tumor syndromes involving the endocrine organs is focused on
discussing the main updates on the upcoming fifth edition of the WHO Classification of …

Medullary thyroid carcinoma (MTC), a tumor derived from the neural crest, occurs either
sporadically or as the dominant component of the type 2 multiple endocrine neoplasia …

Genetic variability in humans is influenced by many factors, such as natural selection,
mutations, genetic drift, and migrations. Molecular epidemiology evaluates the contribution …

Over the past decades, the role of rearranged during transfection (RET) alterations in
tumorigenesis has been firmly established. RET kinase inhibition is an essential therapeutic …

Endocrine disorders are known to involve all organ systems of the body, including the skin.
The cutaneous manifestations of endocrine disorders can range from common findings such …

Amyloid deposits can be the cause of many chronic diseases. Primary localized cutaneous
amyloidosis (PLCA) is a chronic dermatologic condition with amyloid deposits in the …

Amyloid is a protein derived from at least 20 different substances. Once misfolded, it results
in a group of cutaneous and systemic conditions. Primary localized cutaneous amyloidosis …

Tyrosine kinase inhibitors are effective therapeutic agents for the treatment of progressive
MTC. Nevertheless, it is not clear who will benefit the most from therapy, and the decision …