A comprehensive review of viral characteristics, transmission, pathophysiology, immune response, and management of SARS-CoV-2 and COVID-19 as a basis for …
COVID-19 emerged from China in December 2019 and during 2020 spread to every
continent including Antarctica. The coronavirus, SARS-CoV-2, has been identified as the …
continent including Antarctica. The coronavirus, SARS-CoV-2, has been identified as the …
A decade of FDA-approved drugs (2010–2019): trends and future directions
A total of 378 novel drugs and 27 biosimilars approved by the US Food and Drug
Administration (FDA) between 2010 and 2019 were evaluated according to approval …
Administration (FDA) between 2010 and 2019 were evaluated according to approval …
Acceptance and attitudes toward COVID-19 vaccines: A cross-sectional study from Jordan
Vaccines are effective interventions that can reduce the high burden of diseases globally.
However, public vaccine hesitancy is a pressing problem for public health authorities. With …
However, public vaccine hesitancy is a pressing problem for public health authorities. With …
A review on drug repurposing applicable to COVID-19
S Dotolo, A Marabotti, A Facchiano… - Briefings in …, 2021 - academic.oup.com
Drug repurposing involves the identification of new applications for existing drugs at a lower
cost and in a shorter time. There are different computational drug-repurposing strategies and …
cost and in a shorter time. There are different computational drug-repurposing strategies and …
In silico Screening of Natural Compounds as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike RBD: Targets for COVID-19
Historically, plants have been sought after as bio-factories for the production of diverse
chemical compounds that offer a multitude of possibilities to cure diseases. To combat the …
chemical compounds that offer a multitude of possibilities to cure diseases. To combat the …
NF-κB signalling as a pharmacological target in COVID-19: potential roles for IKKβ inhibitors
M Kandasamy - Naunyn-Schmiedeberg's archives of pharmacology, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) has been characterized by lymphopenia as
well as a proinflammatory cytokine storm, which are responsible for the poor prognosis and …
well as a proinflammatory cytokine storm, which are responsible for the poor prognosis and …
[HTML][HTML] Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replication
Ivermectin (IVM) is an FDA approved macrocyclic lactone compound traditionally used to
treat parasitic infestations and has shown to have antiviral potential from previous in-vitro …
treat parasitic infestations and has shown to have antiviral potential from previous in-vitro …
RETRACTED: effects of a single dose of ivermectin on viral and clinical outcomes in asymptomatic SARS-CoV-2 infected subjects: a pilot clinical trial in Lebanon
AA Samaha, H Mouawia, M Fawaz, H Hassan… - Viruses, 2021 - mdpi.com
Objective: This study was designed to determine the efficacy of ivermectin, an FDA-
approved drug, in producing clinical benefits and decreasing the viral load of SARS-CoV-2 …
approved drug, in producing clinical benefits and decreasing the viral load of SARS-CoV-2 …
COVID-19 lung pathogenesis in SARS-CoV-2 autopsy cases
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health
issue. COVID-19 is considered an airway/multi-systemic disease, and demise has been …
issue. COVID-19 is considered an airway/multi-systemic disease, and demise has been …
An open-label randomized controlled trial evaluating the efficacy of chloroquine/hydroxychloroquine in severe COVID-19 patients
Á Réa-Neto, RS Bernardelli, BMD Câmara, FB Reese… - Scientific reports, 2021 - nature.com
Despite several studies designed to evaluate the efficacy of chloroquine and
hydroxychloroquine in the treatment of coronavirus disease 2019 (COVID-19), there is still …
hydroxychloroquine in the treatment of coronavirus disease 2019 (COVID-19), there is still …