Fear generalization and anxiety: behavioral and neural mechanisms

JE Dunsmoor, R Paz - Biological psychiatry, 2015 - Elsevier
Fear can be an adaptive emotion that helps defend against potential danger. Classical
conditioning models elegantly describe how animals learn which stimuli in the environment …

Fear generalization in humans: systematic review and implications for anxiety disorder research

S Dymond, JE Dunsmoor, B Vervliet, B Roche… - Behavior therapy, 2015 - Elsevier
Fear generalization, in which conditioned fear responses generalize or spread to related
stimuli, is a defining feature of anxiety disorders. The behavioral consequences of …

Laboratory models of post-traumatic stress disorder: The elusive bridge to translation

JE Dunsmoor, JM Cisler, GA Fonzo, SK Creech… - Neuron, 2022 - cell.com
Post-traumatic stress disorder (PTSD) is a debilitating mental illness composed of a
heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a …

Ventromedial prefrontal cortex reactivity is altered in generalized anxiety disorder during fear generalization

T Greenberg, JM Carlson, J Cha, G Hajcak… - Depression and …, 2013 - Wiley Online Library
Background Fear generalization is thought to contribute to the development and
maintenance of anxiety symptoms and accordingly has been the focus of recent research …

[HTML][HTML] Pain: a precision signal for reinforcement learning and control

B Seymour - Neuron, 2019 - cell.com
Since noxious stimulation usually leads to the perception of pain, pain has traditionally been
considered sensory nociception. But its variability and sensitivity to a broad array of …

Fear one, fear them all: A systematic review and meta-analysis of fear generalization in pathological anxiety

L Fraunfelter, ABM Gerdes, GW Alpers - Neuroscience & Biobehavioral …, 2022 - Elsevier
It is a defining feature of anxiety disorders that fear is elicited by a circumscribed class of
stimuli rather than by only one specific exemplar of that class. Therefore, fear generalization …

[HTML][HTML] The relation between anxious personality traits and fear generalization in healthy subjects: A systematic review and meta-analysis

MSC Sep, A Steenmeijer, M Kennis - Neuroscience & Biobehavioral …, 2019 - Elsevier
Background Anxious personality characteristics form a risk factor for anxiety disorders. A
proposed mechanistic pathway is that anxious personality could lead to greater vulnerability …

Role of conceptual knowledge in learning and retention of conditioned fear

JE Dunsmoor, A Martin, KS LaBar - Biological psychology, 2012 - Elsevier
Associating sensory cues with aversive outcomes is a relatively basic process shared across
species. Yet higher-order cognitive processes likely contribute to associative fear learning in …

Maladaptive behavioral consequences of conditioned fear-generalization: a pronounced, yet sparsely studied, feature of anxiety pathology

B van Meurs, N Wiggert, I Wicker, S Lissek - Behaviour research and …, 2014 - Elsevier
Fear-conditioning experiments in the anxiety disorders focus almost exclusively on passive-
emotional, Pavlovian conditioning, rather than active-behavioral, instrumental conditioning …

Generalization of human fear acquisition and extinction within a novel arbitrary stimulus category

E Vervoort, B Vervliet, M Bennett, F Baeyens - PloS one, 2014 - journals.plos.org
Adaptive anxiety relies on a balance between the generalization of fear acquisition and fear
extinction. Research on fear (extinction) generalization has focused mostly on perceptual …