The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

This review outlines the accomplishments and potential developments of targeted alpha (α)
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …

Among all existing radionuclides, only a few are of interest for therapeutic applications and
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …

Purpose The aim of the present paper is to review the role of HER2 antibodies, affibodies
and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including …

Targeted therapy and immunotherapy have become mainstream in cancer treatment.
However, only patient subsets benefit from these expensive therapies, and often responses …

Membrane proteins are a crucial class of therapeutic targets that remain challenging to
modulate using traditional occupancy-driven inhibition strategies or current proteolysis …

The promising characteristics of the 7.2-h radiohalogen 211 At have long been recognized;
including having chemical properties suitable for labeling targeting vectors ranging from …

Despite the consensus around the clinical potential of the α-emitting radionuclide astatine-
211 (211At), there are only a limited number of research facilities that work with this nuclide …

Theranostics, a promising modern concept combining diagnostic capabilities and
therapeutic effects, has been used for optimizing and personalizing the treatment of many …

Human epidermal growth factor receptor type 2 (HER2) is overexpressed in numerous
carcinomas. Nanobodies (Nbs) are the smallest antibody-derived fragments with beneficial …