A literature review of traumatic brain injury biomarkers

HS Ghaith, AA Nawar, MD Gabra… - Molecular …, 2022 - Springer
Research into TBI biomarkers has accelerated rapidly in the past decade owing to the
heterogeneous nature of TBI pathologies and management, which pose challenges to TBI …

Traumatic brain injury: classification, models, and markers

D Najem, K Rennie… - … and cell biology, 2018 - cdnsciencepub.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Due to
its high incidence rate and often long-term sequelae, TBI contributes significantly to …

Early predictors of outcome after mild traumatic brain injury (UPFRONT): an observational cohort study

J van der Naalt, ME Timmerman, ME de Koning… - The Lancet …, 2017 - thelancet.com
Background Mild traumatic brain injury (mTBI) accounts for most cases of TBI, and many
patients show incomplete long-term functional recovery. We aimed to create a prognostic …

Concussion as a multi-scale complex system: an interdisciplinary synthesis of current knowledge

ES Kenzie, EL Parks, ED Bigler, MM Lim… - Frontiers in …, 2017 - frontiersin.org
Traumatic brain injury (TBI) has been called “the most complicated disease of the most
complex organ of the body” and is an increasingly high-profile public health issue. Many …

Assessing neuronal and astrocyte derived exosomes from individuals with mild traumatic brain injury for markers of neurodegeneration and cytotoxic activity

CN Winston, HK Romero, M Ellisman… - Frontiers in …, 2019 - frontiersin.org
Mild traumatic brain injury (mTBI) disproportionately affects military service members and is
very difficult to diagnose. To-date, there is currently no blood-based, diagnostic biomarker …

Multiparametric MRI changes persist beyond recovery in concussed adolescent hockey players

KY Manning, A Schranz, R Bartha, GA Dekaban… - Neurology, 2017 - AAN Enterprises
Objective: To determine whether multiparametric MRI data can provide insight into the acute
and long-lasting neuronal sequelae after a concussion in adolescent athletes. Methods …

[HTML][HTML] Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathy

NK Evanson, F Guilhaume-Correa, JP Herman… - PLoS …, 2018 - journals.plos.org
Adult male C57BL/6J mice have previously been reported to have motor and memory
deficits after experimental closed head traumatic brain injury (TBI), without associated gross …

Mild, moderate and severe: terminology implications for clinical and experimental traumatic brain injury

S Yamamoto, HS Levin, DS Prough - Current opinion in …, 2018 - journals.lww.com
Many patients after mild or moderate TBI suffer long-term sequelae and should be
considered a major target for translational research. Treatments that improve outcome in …

The evolving role of extracellular vesicles (exosomes) as biomarkers in traumatic brain injury: Clinical perspectives and therapeutic implications

NA Khan, M Asim, A El-Menyar, KH Biswas… - Frontiers in Aging …, 2022 - frontiersin.org
Developing effective disease-modifying therapies for neurodegenerative diseases (NDs)
requires reliable diagnostic, disease activity, and progression indicators. While desirable …

[HTML][HTML] Scared or scarred: Could 'dissociogenic'lesions predispose to nonepileptic seizures after head trauma?

S Popkirov, AJ Carson, J Stone - Seizure, 2018 - Elsevier
A history of head injury is common in patients with psychogenic nonepileptic seizures
(PNES). This association has so far been interpreted as either spurious or psychologically …